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Peptide record

TPDB11551

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB11551
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SFLTTVKKLVTNLAALAGTVIDTIKCKVTGGCRT
Physicochemical Analysis
C155H272N42O46S2
EQHMPWY
T
3524.24
10.17
5
1
14
+4
2.86
0.594
111.76
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
3.55
11
Residue Composition
number
3
A
1
R
1
N
1
D
2
C
0
E
0
Q
3
G
0
H
2
I
4
L
4
K
0
M
1
F
0
P
1
S
7
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 4 K: 4 M: 0 F: 1 P: 0 S: 1 T: 7 W: 0 Y: 0 V: 4
Chemical Descriptors
34
C155H272N42O46S2
3524.24
10.17
+4
2.86
0.594
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 8 uM), E. coli (MIC 8 uM), MRSA (MIC 16 uM), and C. albicans (MIC 8 uM). kill bacteria and cand
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 8 uM), E. coli (MIC 8 uM), MRSA (MIC 16 uM), and C. albicans (MIC 8 uM). kill bacteria and candida at similar conce
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 8 uM), E. coli (MIC 8 uM), MRSA (MIC 16 uM), and C. albicans (MIC 8 uM). kill bacteria and candida at similar concentraitons.
Evidence 4 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 8 uM), E. coli (MIC 8 uM), MRSA (MIC 16 uM), and C. albicans (MIC 8 uM). kill bacteria and cand
Evidence 5 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 8 uM), E. coli (MIC 8 uM), MRSA (MIC 16 uM), and C. albicans (MIC 8 uM). kill bacteria and candida at similar conce
Evidence 6 Activity

Activity

MIC
Antifungal
8 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 8 uM), E. coli (MIC 8 uM), MRSA (MIC 16 uM), and C. albicans (MIC 8 uM). kill bacteria and candida at similar concentraitons.
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
16.11 µM
Hemolytic Cytotoxic
50% Hemolysis | 16.11 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and its Truncated Analogues. | Biomolecules | 2019
Evidence 8 Activity

Activity

% Hemolysis
Toxicity
7 %
Hemolytic
Hemolytic_activity: [Ref.31242693] 7% hemolysis at 2 µM, 23% hemolysis at 8 µM, 50% hemolysis at 16 µM, 71% hemolysis at 32 µM, 100% hemolysis at 64 µM on horse erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomolecules. 2019 Jun 25 9(6):249. doi: 10.3390/biom9060249.
Evidence 9 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis