Back to search

Peptide record

TPDB11540

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11540
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRFKKFFKKLKNSVKKRAKKFFKKPKVIGVTFPF
Physicochemical Analysis
C206H334N54O38
DCEQHMWY
K
4175.26
12.51
15
0
13
+15
7.35
-0.765
51.47
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
13
K
0
M
7
F
2
P
1
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 13 M: 0 F: 7 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
34
C206H334N54O38
4175.26
12.51
+15
7.35
-0.765
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- and Gram+ bacteria (A. actinomycetemcomitans, E. coli, F. novicida, P. aeruginosa, B. thailandensis, and S. aureus) ( Amer L et al., 2010 de Latour F et al., 2010 Dean S et al., 2011a Dean S et al., 2011b ) at concentrations Blower et al., 2018 ). It also has anti-biofilm activity against S. aureus ( Dean S et al., 2011a ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- and Gram+ bacteria (A. actinomycetemcomitans, E. coli, F. novicida, P. aeruginosa, B. thailandensis, and S. aureus) ( Amer L et al., 2010 de Latour F et al., 2010 Dean S et al., 2011a Dean S et al., 2011b ) at concentrations Blower et al., 2018 ). It also has anti-biofilm activity against S. aureus ( Dean S et al., 2011a ).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against Gram- and Gram+ bacteria (A. actinomycetemcomitans, E. coli, F. novicida, P. aeruginosa, B. thailandensis, and S. aureus) ( Amer L et al., 2010 de Latour F et al., 2010 Dean S et al., 2011a Dean S et al., 2011b ) at concentrations Blower et al., 2018 ). It also has anti-biofilm activity against S. aureus ( Dean S et al., 2011a ).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

Active against Gram- and Gram+ bacteria (A. actinomycetemcomitans, E. coli, F. novicida, P. aeruginosa, B. thailandensis, and S. aureus) ( Amer L et al., 2010 de Latour F et al., 2010 Dean S et al., 2011a Dean S et al., 2011b ) at concentrations Blower et al., 2018 ). It also has anti-biofilm activity against S. aureus ( Dean S et al., 2011a ).
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.28089718] 0% hemolysis at 300µg/ml against sheep red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Dev Comp Immunol. 2017 May 70:135-144.
Evidence 7 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.