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Peptide record

TPDB11539

Psacotheasin Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB11539
Psacotheasin
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifp Antifungipept CAFPdb ToxinPred 3.0 DBAASP
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
CIAKGNGCQPSGVQGNCCSGHCHKEPGWVAGYCK
Physicochemical Analysis
C143H220N46O44S6
RDLMFT
G
3479.96
8.02
5
1
7
+2
5.40
-0.409
34.41
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
7365
211.64
13
Residue Composition
number
2
A
0
R
2
N
0
D
6
C
1
E
2
Q
7
G
2
H
1
I
0
L
3
K
0
M
0
F
2
P
2
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 6 E: 1 Q: 2 G: 7 H: 2 I: 1 L: 0 K: 3 M: 0 F: 0 P: 2 S: 2 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
34
C143H220N46O44S6
3479.96
8.02
+2
5.40
-0.409
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

E. faecium ATCC 29212

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against tested Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram-
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

P. acnes ATCC 6919

Source & Reference

dbAMP

Other

active against tested Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

d Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 2
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli O-157 ATCC 43895

Source & Reference

dbAMP

Other

s ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 27853 (MIC 25 uM). Also active against C. albicans.
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

CC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 27853 (MIC 25 uM). Also active against C. albicans.
Evidence 6 Activity

Activity

MIC
Antifungal
25 µM

Target

E. faecium ATCC 29212

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against tested Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram-
Evidence 7 Activity

Activity

MIC
Antifungal
12.5 µM

Target

P. acnes ATCC 6919

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against tested Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895
Evidence 8 Activity

Activity

MIC
Antifungal
25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

d Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 2
Evidence 9 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli O-157 ATCC 43895

Source & Reference

dbAMP CAFPdb Antifungipept

Other

s ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 27853 (MIC 25 uM). Also active against C. albicans.
Evidence 10 Activity

Activity

MIC
Antifungal
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

CC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 27853 (MIC 25 uM). Also active against C. albicans.
Evidence 11 Activity

Activity

MIC
Antiparasitic
25 µM

Target

E. faecium ATCC 29212

Source & Reference

NA

Other

active against tested Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram-
Evidence 12 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

P. acnes ATCC 6919

Source & Reference

NA

Other

active against tested Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895
Evidence 13 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

d Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 2
Evidence 14 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Escherichia coli O-157 ATCC 43895

Source & Reference

NA

Other

s ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 27853 (MIC 25 uM). Also active against C. albicans.
Evidence 15 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

CC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 27853 (MIC 25 uM). Also active against C. albicans.
Evidence 16 Activity

Activity

MIC
Antiviral
25 µM

Target

E. faecium ATCC 29212

Source & Reference

NA

Other

active against tested Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram-
Evidence 17 Activity

Activity

MIC
Antiviral
12.5 µM

Target

P. acnes ATCC 6919

Source & Reference

NA

Other

active against tested Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895
Evidence 18 Activity

Activity

MIC
Antiviral
25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

d Gram+ bacteria E. faecium ATCC 29212 (MIC 25 uM), P. acnes ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 2
Evidence 19 Activity

Activity

MIC
Antiviral
12.5 µM

Target

Escherichia coli O-157 ATCC 43895

Source & Reference

NA

Other

s ATCC 6919 (MIC 12.5 uM), and S. aureus ATCC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 27853 (MIC 25 uM). Also active against C. albicans.
Evidence 20 Activity

Activity

MIC
Antiviral
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

CC 25923 (MIC 25 uM) as well as Gram- bacteria E. coli O-157 ATCC 43895 (MIC 12.5 uM) and P. aeruginosa ATCC 27853 (MIC 25 uM). Also active against C. albicans.
Evidence 21 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal properties and mode of action of psacotheasin, a novel knottin-type peptide derived from Psacothea hilaris. | Biochem Biophys Res Commun | 2010
Evidence 22 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP