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Peptide record

TPDB11537

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

34 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11537

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP pep-lab Peptipedia AFP-GFuse Antifungipept CAFPdb i2APP AI4AVP dbAMP 3.0 DRAVP 2.0

Sequence_Type

standard

Has_Modification No

Description A 34-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

SCASRCKGHCRARRCGYYVSVLYRGRCYCKCLRC

FASTA

>TPDB11537|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=34
SCASRCKGHCRARRCGYYVSVLYRGRCYCKCLRC

Formula C163H267N59O42S8

Absent Amino Acids NDEQIMFPTW

Common Amino Acids C

Mass 3981.76

PI 9.52

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +9

Boman Index 2.03

Hydrophobicity -0.344

Aliphatic Index 45.88

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6460

Absorbance 280nm 162.24

Polar Residues 15

number

Amino Acid Distribution

A: 2 R: 7 N: 0 D: 0 C: 8 E: 0 Q: 0 G: 3 H: 1 I: 0 L: 2 K: 2 M: 0 F: 0 P: 0 S: 3 T: 0 W: 0 Y: 4 V: 2

Length

Formula

C163H267N59O42S8

Mass

3981.76

9.52

Net Charge

Boman Index

2.03

Hydrophobicity

-0.344

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.17-0.35 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram+ M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 u

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.35-0.7 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 uM), Gram- E. coli D31 (MIC 0.7-1.4 uM), B-suis (MIC >11.2 uM

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.17-0.35 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 uM), Gram- E. coli D31 (MIC 0.7-1.4 uM), B-suis (MIC >11.2 uM), P-aeruginosa (MIC >11.2 uM),

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.7-1.4 µM

Target

Target Organism Escherichia coli D31

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 uM), Gram- E. coli D31 (MIC 0.7-1.4 uM), B-suis (MIC >11.2 uM), P-aeruginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. al

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.8 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, Gram- E. coli D31 (MIC 0.7-1.4 uM), B-suis (MIC >11.2 uM), P-aeruginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

4 uM), B-suis (MIC >11.2 uM), P-aeruginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.17-0.35 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

enes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.7-1.4 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.17-0.35 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram+ M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 u

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.35-0.7 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 uM), Gram- E. coli D31 (MIC 0.7-1.4 uM), B-suis (MIC >11.2 uM

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.17-0.35 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.7-1.4 µM

Target

Target Organism Escherichia coli D31

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.8 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

uginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.17-0.35 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

enes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.7-1.4 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.17-0.35 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against Gram+ M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 u

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.35-0.7 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 uM), Gram- E. coli D31 (MIC 0.7-1.4 uM), B-suis (MIC >11.2 uM

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.17-0.35 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.7-1.4 µM

Target

Target Organism Escherichia coli D31

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.8 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

uginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.17-0.35 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

enes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.7-1.4 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.17-0.35 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against Gram+ M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 u

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.35-0.7 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.17-0.35 uM), S-aureus (MIC >5.6 uM), L. monocytogenes (MIC 0.35-0.7 uM), E. faecalis (MIC 0.17-0.35 uM), Gram- E. coli D31 (MIC 0.7-1.4 uM), B-suis (MIC >11.2 uM

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.17-0.35 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.7-1.4 µM

Target

Target Organism Escherichia coli D31

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.4-2.8 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

uginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.17-0.35 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

enes (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.7-1.4 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 0.17-0.35 uM), and fungi F. oxysporum (MIC 0.7-1.4 uM).