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Peptide record

TPDB11535

DRS S1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11535
DRS S1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 AI4AVP DRAVP 2.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ
Physicochemical Analysis
C152H257N43O44S2
RNCEFPYV
A
3455.09
10.55
5
1
17
+3
1.26
0.185
92.35
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
159.19
7
Residue Composition
number
8
A
0
R
0
N
1
D
0
C
0
E
2
Q
4
G
1
H
1
I
5
L
4
K
2
M
0
F
0
P
1
S
4
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 2 G: 4 H: 1 I: 1 L: 5 K: 4 M: 2 F: 0 P: 0 S: 1 T: 4 W: 1 Y: 0 V: 0
Chemical Descriptors
34
C152H257N43O44S2
3455.09
10.55
+3
1.26
0.185
Free
L
Linear
Free
Antimicrobial
Dermaseptins B
Evidence Records 55 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

A. caviae IP67-16T

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasi
Evidence 2 Activity

Activity

MIC
Antibacterial
1 µM

Target

Escherichia coli IP76-24

Source & Reference

dbAMP DRAMP

Other

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM)
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus aureus IP76-25

Source & Reference

dbAMP DRAMP

Other

gainst A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP8
Evidence 4 Activity

Activity

MIC
Antibacterial
35 µM

Target

N. brasiliensis IP118079

Source & Reference

dbAMP DRAMP

Other

0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neofor
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µM

Target

S. cerevisiae IP118079

Source & Reference

dbAMP DRAMP

Other

E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5
Evidence 6 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

C. neoformans IP960-67 and IP962-67

Source & Reference

dbAMP DRAMP

Other

IC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71
Evidence 7 Activity

Activity

MIC
Antibacterial
15 µM

Target

M. canis IP1194

Source & Reference

dbAMP DRAMP

Other

icans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-
Evidence 8 Activity

Activity

MIC
Antibacterial
35 µM

Target

T. rubrum IP2043-92

Source & Reference

dbAMP DRAMP

Other

10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii
Evidence 9 Activity

Activity

MIC
Antibacterial
20 µM

Target

T. metagrophytes IP877-71

Source & Reference

dbAMP DRAMP

Other

nd IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and
Evidence 10 Activity

Activity

MIC
Antibacterial
15 µM

Target

A. simii J43

Source & Reference

dbAMP DRAMP

Other

IC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E
Evidence 11 Activity

Activity

MIC
Antibacterial
30 µM

Target

A. fumigatus IP1025-70

Source & Reference

dbAMP DRAMP

Other

, A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against L. major
Evidence 12 Activity

Activity

MIC
Antibacterial
12 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against L. major (Perez-Cordero JJ et al. 2011 Peptides 32 (4), 68
Evidence 13 Activity

Activity

Not Available
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

Thymidine Incorporation assay
6-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1998

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 14 Activity

Activity

MIC
Antifungal
0.5 µM

Target

A. caviae IP67-16T

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasi
Evidence 15 Activity

Activity

MIC
Antifungal
1 µM

Target

Escherichia coli IP76-24

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM)
Evidence 16 Activity

Activity

MIC
Antifungal
5 µM

Target

Staphylococcus aureus IP76-25

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

gainst A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP8
Evidence 17 Activity

Activity

MIC
Antifungal
35 µM

Target

N. brasiliensis IP118079

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neofor
Evidence 18 Activity

Activity

MIC
Antifungal
5 µM

Target

S. cerevisiae IP118079

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5
Evidence 19 Activity

Activity

MIC
Antifungal
0.5-1 µM

Target

C. neoformans IP960-67 and IP962-67

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71
Evidence 20 Activity

Activity

MIC
Antifungal
15 µM

Target

M. canis IP1194

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

icans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-
Evidence 21 Activity

Activity

MIC
Antifungal
35 µM

Target

T. rubrum IP2043-92

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii
Evidence 22 Activity

Activity

MIC
Antifungal
20 µM

Target

T. metagrophytes IP877-71

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nd IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and
Evidence 23 Activity

Activity

MIC
Antifungal
15 µM

Target

A. simii J43

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E
Evidence 24 Activity

Activity

MIC
Antifungal
30 µM

Target

A. fumigatus IP1025-70

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against L. major
Evidence 25 Activity

Activity

MIC
Antifungal
12 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against L. major (Perez-Cordero JJ et al. 2011 Peptides 32 (4), 68
Evidence 26 Activity

Activity

MIC
Antiparasitic
0.5 µM

Target

A. caviae IP67-16T

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasi
Evidence 27 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Escherichia coli IP76-24

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM)
Evidence 28 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Staphylococcus aureus IP76-25

Source & Reference

dbAMP 3.0 DRAMP

Other

gainst A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP8
Evidence 29 Activity

Activity

MIC
Antiparasitic
35 µM

Target

N. brasiliensis IP118079

Source & Reference

dbAMP 3.0 DRAMP

Other

0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neofor
Evidence 30 Activity

Activity

MIC
Antiparasitic
5 µM

Target

S. cerevisiae IP118079

Source & Reference

dbAMP 3.0 DRAMP

Other

E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5
Evidence 31 Activity

Activity

MIC
Antiparasitic
0.5-1 µM

Target

C. neoformans IP960-67 and IP962-67

Source & Reference

dbAMP 3.0 DRAMP

Other

IC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71
Evidence 32 Activity

Activity

MIC
Antiparasitic
15 µM

Target

M. canis IP1194

Source & Reference

dbAMP 3.0 DRAMP

Other

icans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-
Evidence 33 Activity

Activity

MIC
Antiparasitic
35 µM

Target

T. rubrum IP2043-92

Source & Reference

dbAMP 3.0 DRAMP

Other

10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii
Evidence 34 Activity

Activity

MIC
Antiparasitic
20 µM

Target

T. metagrophytes IP877-71

Source & Reference

dbAMP 3.0 DRAMP

Other

nd IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and
Evidence 35 Activity

Activity

MIC
Antiparasitic
15 µM

Target

A. simii J43

Source & Reference

dbAMP 3.0 DRAMP

Other

IC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E
Evidence 36 Activity

Activity

MIC
Antiparasitic
30 µM

Target

A. fumigatus IP1025-70

Source & Reference

dbAMP 3.0 DRAMP

Other

, A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against L. major
Evidence 37 Activity

Activity

MIC
Antiparasitic
12 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against L. major (Perez-Cordero JJ et al. 2011 Peptides 32 (4), 68
Evidence 38 Activity

Activity

MIC
Antiviral
0.5 µM

Target

A. caviae IP67-16T

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasi
Evidence 39 Activity

Activity

MIC
Antiviral
1 µM

Target

Escherichia coli IP76-24

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM)
Evidence 40 Activity

Activity

MIC
Antiviral
5 µM

Target

Staphylococcus aureus IP76-25

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

gainst A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP8
Evidence 41 Activity

Activity

MIC
Antiviral
35 µM

Target

N. brasiliensis IP118079

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neofor
Evidence 42 Activity

Activity

MIC
Antiviral
5 µM

Target

S. cerevisiae IP118079

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5
Evidence 43 Activity

Activity

MIC
Antiviral
0.5-1 µM

Target

C. neoformans IP960-67 and IP962-67

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

IC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71
Evidence 44 Activity

Activity

MIC
Antiviral
15 µM

Target

M. canis IP1194

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

icans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-
Evidence 45 Activity

Activity

MIC
Antiviral
35 µM

Target

T. rubrum IP2043-92

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii
Evidence 46 Activity

Activity

MIC
Antiviral
20 µM

Target

T. metagrophytes IP877-71

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

nd IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and
Evidence 47 Activity

Activity

MIC
Antiviral
15 µM

Target

A. simii J43

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

IC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E
Evidence 48 Activity

Activity

MIC
Antiviral
30 µM

Target

A. fumigatus IP1025-70

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

, A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against L. major
Evidence 49 Activity

Activity

MIC
Antiviral
12 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against L. major (Perez-Cordero JJ et al. 2011 Peptides 32 (4), 68
Evidence 50 Activity

Activity

50% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Leishmanicidal activity of synthetic antimicrobial peptides in an infection model with human dendritic cells. | Peptides | 2011
Evidence 51 Activity

Activity

50% Cell death
Toxicity
10.66±0.23 µg/mL
Cytotoxic
50% Cell death | 10.66±0.23 | µg/mL | target cell: Human dendritic cells

Target

Human dendritic cells

Source & Reference

NA
DBAASP
Leishmanicidal activity of synthetic antimicrobial peptides in an infection model with human dendritic cells. | Peptides | 2011
Evidence 52 Activity

Activity

50% cytotoxicity
Toxicity
25 µM
Cytotoxic
50% cytotoxicity | 25 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 53 Activity

Activity

50% Cytotoxicity
Toxicity
45 µM
Cytotoxic
50% Cytotoxicity | 45 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
In vitro activity of dermaseptin S1 derivatives against genital pathogens. | APMIS | 2010
Evidence 54 Activity

Activity

IC50
Toxicity
20.51 µM
Cytotoxic
IC50 | 20.51 | µM | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Targeted delivery of antimicrobial peptide by Cry protein crystal to treat intramacrophage infection. | Biomaterials | 2019
Evidence 55 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.