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Peptide record

TPDB11525

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB11525
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRFKKFFKKLKNSVKKRAKKFFKKPRVIGVSIPF
Physicochemical Analysis
C202H334N56O38
DCEQHMTWY
K
4155.23
12.75
15
0
13
+15
7.98
-0.735
62.94
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
3
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
1
L
12
K
0
M
6
F
2
P
2
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 12 M: 0 F: 6 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
34
C202H334N56O38
4155.23
12.75
+15
7.98
-0.735
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-25 µg/mL

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. p
Evidence 2 Activity

Activity

MIC
Antibacterial
4-6.25 µg/mL

Target

Enterobacter aerogenes

Source & Reference

dbAMP DRAMP

Other

Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. fae
Evidence 3 Activity

Activity

MIC
Antibacterial
6-20 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

t E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1
Evidence 5 Activity

Activity

MIC
Antibacterial
3.1 µg/mL

Target

H. influenzae

Source & Reference

dbAMP DRAMP

Other

. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
6.25-12.5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

ae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 7 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
1-25 µg/mL

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. p
Evidence 9 Activity

Activity

MIC
Antifungal
4-6.25 µg/mL

Target

Enterobacter aerogenes

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. fae
Evidence 10 Activity

Activity

MIC
Antifungal
6-20 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml
Evidence 11 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

t E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1
Evidence 12 Activity

Activity

MIC
Antifungal
3.1 µg/mL

Target

H. influenzae

Source & Reference

dbAMP DRAMP Antifungipept

Other

. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 13 Activity

Activity

MIC
Antifungal
6.25-12.5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

ae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 14 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP Antifungipept

Other

25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 15 Activity

Activity

MIC
Antiparasitic
1-25 µg/mL

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. p
Evidence 16 Activity

Activity

MIC
Antiparasitic
4-6.25 µg/mL

Target

Enterobacter aerogenes

Source & Reference

DRAMP

Other

Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. fae
Evidence 17 Activity

Activity

MIC
Antiparasitic
6-20 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Active against E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml
Evidence 18 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

t E. cloacae (MIC 1-25 ug/ml), E. aerogenes (MIC 4-6.25 ug/ml), E. coli (MIC 6-20 ug/ml), S. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1
Evidence 19 Activity

Activity

MIC
Antiparasitic
3.1 µg/mL

Target

H. influenzae

Source & Reference

DRAMP

Other

. aureus (MIC 4 ug/ml), K. pneumoniae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 20 Activity

Activity

MIC
Antiparasitic
6.25-12.5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

ae (3.1-6.2 ug/ml), E. faecalis ATCC 29212 (25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 21 Activity

Activity

MIC
Antiparasitic
>200 µg/mL

Target

C.albicans

Source & Reference

DRAMP

Other

25 ug/ml), H. influenzae (MIC 3.1 ug/ml), and P. aeruginosa (MIC 6.25-12.5 ug/ml). fungi: C.albicans (MIC >200 ug/ml).
Evidence 22 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and characterization of novel reptile cathelicidins from elapid snakes | Peptides | 2008
Evidence 23 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. | Amino Acids | 2014