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Peptide record

TPDB11524

Anti-inflammatory Antibacterial Antifungal Toxicity standard

34 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11524

Activity

Anti-inflammatory Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides

Database_Source

Peptipedia AntiBP3 AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 34-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

LIQRGRFGRFLGRIRRFRPRINFDIRARGSIRLG

FASTA

>TPDB11524|Anti-inflammatory;Antibacterial;Antifungal;Toxicity|length=34
LIQRGRFGRFLGRIRRFRPRINFDIRARGSIRLG

Formula C184H309N69O40

Absent Amino Acids CEHKMTWYV

Common Amino Acids R

Mass 4127.92

PI 13.05

Basic Residues 11

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +10

Boman Index 3.85

Hydrophobicity -0.515

Aliphatic Index 94.71

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 1 R: 11 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 5 H: 0 I: 5 L: 3 K: 0 M: 0 F: 4 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C184H309N69O40

Mass

4127.92

13.05

Net Charge

+10

Boman Index

3.85

Hydrophobicity

-0.515

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75-37.5 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC27853

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli ATCC25922, E. coli 08040726, K. Trevisan 1400, P. aeruginosa ATCC27853 (MIC 18.75-37.5 ug/ml), S. maltophilia 7407 (MIC 75 ug/ml), Gram+ S. aureus ATCC27853, S. aureus 08032706, S. au

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism Stenotrophomonas maltophilia 7407

Source & Reference

Database Source dbAMP

Other

Evidence Text

5922, E. coli 08040726, K. Trevisan 1400, P. aeruginosa ATCC27853 (MIC 18.75-37.5 ug/ml), S. maltophilia 7407 (MIC 75 ug/ml), Gram+ S. aureus ATCC27853, S. aureus 08032706, S. aureus 08032712, S. aureus 08032810, S

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.4-18.8 µg/mL

Target

Target Organism B. cereus 1373

Source & Reference

Database Source dbAMP

Other

Evidence Text

CC27853, S. aureus 08032706, S. aureus 08032712, S. aureus 08032810, S. aureus gz130623 , B. cereus 1373 (MIC 9.4-18.8 ug/ml), B. subtilis 1345, E. faecalis 1396 (MIC 75 ug/ml), fungi C. albicans ATCC2002, C. albica

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism Enterococcus faecalis 1396

Source & Reference

Database Source dbAMP

Other

Evidence Text

eus 08032810, S. aureus gz130623 , B. cereus 1373 (MIC 9.4-18.8 ug/ml), B. subtilis 1345, E. faecalis 1396 (MIC 75 ug/ml), fungi C. albicans ATCC2002, C. albicans 08022821, C. albicans 08030809 (MIC 37.5-75 ug/m

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 37.5-75 µg/mL

Target

Target Organism Candida albicans 08030809

Source & Reference

Database Source dbAMP

Other

Evidence Text

1345, E. faecalis 1396 (MIC 75 ug/ml), fungi C. albicans ATCC2002, C. albicans 08022821, C. albicans 08030809 (MIC 37.5-75 ug/ml), and C. glabrata 08A802 (MIC 18.8).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75-37.5 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC27853

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µg/mL

Target

Target Organism Stenotrophomonas maltophilia 7407

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.4-18.8 µg/mL

Target

Target Organism B. cereus 1373

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µg/mL

Target

Target Organism Enterococcus faecalis 1396

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 37.5-75 µg/mL

Target

Target Organism Candida albicans 08030809

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

1345, E. faecalis 1396 (MIC 75 ug/ml), fungi C. albicans ATCC2002, C. albicans 08022821, C. albicans 08030809 (MIC 37.5-75 ug/ml), and C. glabrata 08A802 (MIC 18.8).

Evidence 11 Activity

Activity

Activity Endpoint 13% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

13% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel Cathelicidins from Pigeon Highlights Evolutionary Convergence in Avain Cathelicidins and Functions in Modulation of Innate Immunity. | Sci Rep | 2015