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Peptide record

TPDB11518

Antibacterial Antifungal Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB11518
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RPKKVQGRKAEKDNGDGTTAANASGKKKSSNVFK
Physicochemical Analysis
C151H260N52O50
CHILMWY
K
3604.04
10.97
10
3
7
+7
15.35
-1.568
28.82
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
9
Residue Composition
number
4
A
2
R
3
N
2
D
0
C
1
E
1
Q
4
G
0
H
0
I
0
L
8
K
0
M
1
F
1
P
3
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 2 N: 3 D: 2 C: 0 E: 1 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 8 M: 0 F: 1 P: 1 S: 3 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
34
C151H260N52O50
3604.04
10.97
+7
15.35
-1.568
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.7-5.5 µg/mL

Target

M. luteus

Source & Reference

NA

Other

against Gram- E. coli (MIC ~2.7 ug/ml), A. hydrophila (2.7-5.5 ug/ml), Gram+ B. subtilis, M. luteus (MIC 2.7-5.5 ug/ml) and S. epidermidis (5.5-11 ug/ml). Updated 8/2018.
Evidence 2 Activity

Activity

MIC
Antifungal
2.7-5.5 µg/mL

Target

M. luteus

Source & Reference

Antifungipept

Other

against Gram- E. coli (MIC ~2.7 ug/ml), A. hydrophila (2.7-5.5 ug/ml), Gram+ B. subtilis, M. luteus (MIC 2.7-5.5 ug/ml) and S. epidermidis (5.5-11 ug/ml). Updated 8/2018.
Evidence 3 Activity

Activity

25% Killing
Toxicity
22 µg/mL
Cytotoxic
25% Killing | 22 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Identification of the first cathelicidin gene from skin of Chinese giant salamanders Andrias davidianus with its potent antimicrobial activity. | Dev Comp Immunol | 2017
Evidence 4 Activity

Activity

40% Killing
Toxicity
44 µg/mL
Cytotoxic
40% Killing | 44 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Identification of the first cathelicidin gene from skin of Chinese giant salamanders Andrias davidianus with its potent antimicrobial activity. | Dev Comp Immunol | 2017
Evidence 5 Activity

Activity

55% Killing
Toxicity
88 µg/mL
Cytotoxic
55% Killing | 88 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Identification of the first cathelicidin gene from skin of Chinese giant salamanders Andrias davidianus with its potent antimicrobial activity. | Dev Comp Immunol | 2017