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Peptide record

TPDB11517

Antibacterial Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB11517
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 34-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GFGLGGLARILCLGNRQWSNFFKKLNRKCAMVKK
Physicochemical Analysis
C174H285N53O40S3
DEHPTY
GLK
3855.69
11.58
8
0
14
+8
0.07
-0.121
83.24
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
145.89
7
Residue Composition
number
2
A
3
R
3
N
0
D
2
C
0
E
1
Q
5
G
0
H
1
I
5
L
5
K
1
M
3
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 3 D: 0 C: 2 E: 0 Q: 1 G: 5 H: 0 I: 1 L: 5 K: 5 M: 1 F: 3 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
34
C174H285N53O40S3
3855.69
11.58
+8
0.07
-0.121
Evidence Records 2 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

active against E-coli ATCC 25922 (MIC >50 uM) and S. aureus ATCC 25923 (MIC 12.5 uM). Warning: other bacteria not tested.
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An engineered arginine-rich ?-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice. | Sci Rep | 2018