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Peptide record

TPDB11516

Antibacterial Anticancer Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB11516
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GFALAGLARILCLWFREFSGFFRRLNRRFAMRRR
Physicochemical Analysis
C193H301N63O39S2
DQHKPTYV
R
4192.03
12.70
9
1
18
+8
-3.00
0.044
80.59
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
131.20
3
Residue Composition
number
4
A
9
R
1
N
0
D
1
C
1
E
0
Q
3
G
0
H
1
I
5
L
0
K
1
M
6
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 9 N: 1 D: 0 C: 1 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 5 K: 0 M: 1 F: 6 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
34
C193H301N63O39S2
4192.03
12.70
+8
-3.00
0.044
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), A. baumannii (MIC 1 uM), and S. aureus ATCC 25923 or MRSA (MIC 1-6.25 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
1 µM

Target

A. baumannii

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), A. baumannii (MIC 1 uM), and S. aureus ATCC 25923 or MRSA (MIC 1-6.25 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
1-6.25 µM

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6.25 uM), A. baumannii (MIC 1 uM), and S. aureus ATCC 25923 or MRSA (MIC 1-6.25 uM).
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An engineered arginine-rich ?-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice. | Sci Rep | 2018
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
An engineered arginine-rich ?-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice. | Sci Rep | 2018