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Peptide record

TPDB11503

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

34 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11503

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 pep-lab Peptipedia dbACP Antifungipept CAFPdb dbAMP AI4AVP dbAMP 3.0 DRAVP 2.0

Sequence_Type

standard

Has_Modification No

Description A 34-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, pep-lab, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ

FASTA

>TPDB11503|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=34
GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ

Formula C178H302N50O46

Absent Amino Acids ADCHMSTWY

Common Amino Acids K

Mass 3878.66

PI 10.74

Basic Residues 9

Acidic Residues 3

Hydrophobic Residues 10

Net Charge +6

Boman Index 13.12

Hydrophobicity -0.894

Aliphatic Index 88.82

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 5

number

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 0 E: 3 Q: 4 G: 5 H: 0 I: 3 L: 4 K: 8 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C178H302N50O46

Mass

3878.66

10.74

Net Charge

Boman Index

13.12

Hydrophobicity

-0.894

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.12 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.12 µM

Target

Target Organism S. typhimurium

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. au

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.12 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. aureus (MIC 3.12 uM), C. albica

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP

Other

Evidence Text

against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. aureus (MIC 3.12 uM), C. albicans (MIC 12. 5 uM), A. fumig

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Streptococcus pyogenes

Source & Reference

Database Source dbAMP

Other

Evidence Text

M), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. aureus (MIC 3.12 uM), C. albicans (MIC 12. 5 uM), A. fumigatus (MIC 12.5 uM), tumor c

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.12 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

2 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. aureus (MIC 3.12 uM), C. albicans (MIC 12. 5 uM), A. fumigatus (MIC 12.5 uM), tumor cells: A549 (IC50 22 uM),

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism A. fumigatus

Source & Reference

Database Source dbAMP

Other

Evidence Text

6.25 uM), S. pyogenes (MIC 6.25 uM), S. aureus (MIC 3.12 uM), C. albicans (MIC 12. 5 uM), A. fumigatus (MIC 12.5 uM), tumor cells: A549 (IC50 22 uM), K562 (IC50 28 uM), Jurkat (IC50 16 uM). It also displaye

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.12 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.12 µM

Target

Target Organism S. typhimurium

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. au

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.12 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. aureus (MIC 3.12 uM), C. albica

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism Streptococcus pyogenes

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.12 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism A. fumigatus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.12 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0

Other

Source Activity Label	Source Definition
Antiparasitic	dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S.

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.12 µM

Target

Target Organism S. typhimurium

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. au

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.12 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. aureus (MIC 3.12 uM), C. albica

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.25 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.25 µM

Target

Target Organism Streptococcus pyogenes

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.12 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µM

Target

Target Organism A. fumigatus

Source & Reference

Database Source dbAMP 3.0

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.12 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S.

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.12 µM

Target

Target Organism S. typhimurium

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. au

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.12 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

active against E. coli (MIC 3.12 uM), S. typhimurium (MIC 3.12 uM), P. aeruginosa (MIC 3.12 uM), B. subtilis (MIC 6.25 uM), S. pyogenes (MIC 6.25 uM), S. aureus (MIC 3.12 uM), C. albica

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µM

Target

Target Organism Streptococcus pyogenes

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.12 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12.5 µM

Target

Target Organism A. fumigatus

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text