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Peptide record

TPDB11495

Antibacterial Anticancer Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11495
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbACP AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
KRMGIFHLFWAGLRKLGNLIKNKIQQGIENFLG
Physicochemical Analysis
C179H287N51O41S1
DCPSTYV
GL
3841.62
11.63
7
1
15
+5
1.35
-0.079
109.39
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
143.17
5
Residue Composition
number
1
A
2
R
3
N
0
D
0
C
1
E
2
Q
5
G
1
H
4
I
5
L
4
K
1
M
3
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 3 D: 0 C: 0 E: 1 Q: 2 G: 5 H: 1 I: 4 L: 5 K: 4 M: 1 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
33
C179H287N51O41S1
3841.62
11.63
+5
1.35
-0.079
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 ug/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. neoformans (MIC 16 ug/mL). Also toxic to Devil Facial Tumour Disease (DFTD) cells ( Petrohilos et al., 2023 ). Upda
Evidence 2 Activity

Activity

MIC
Antifungal
16 ug/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against C. neoformans (MIC 16 ug/mL). Also toxic to Devil Facial Tumour Disease (DFTD) cells ( Petrohilos et al., 2023 ). Upda
Evidence 3 Activity

Activity

5% Hemolysis
Toxicity
1-500 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 1-500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidins in the Tasmanian devil (Sarcophilus harrisii). | Sci Rep | 2016