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Peptide record

TPDB11495

Antibacterial Anticancer Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11495
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbACP AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP ToxinPred 3.0
standard
No
A 33-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
KRMGIFHLFWAGLRKLGNLIKNKIQQGIENFLG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C179H287N51O41S1
DCPSTYV
GL
3841.62
11.63
7
1
15
+5
0.91
-0.079
109.39
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
1.43
5
Residue Composition
number
1
A
2
R
3
N
0
D
0
C
1
E
2
Q
5
G
1
H
4
I
5
L
4
K
1
M
3
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 3 D: 0 C: 0 E: 1 Q: 2 G: 5 H: 1 I: 4 L: 5 K: 4 M: 1 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
33 reviewed residue count
C179H287N51O41S1 sequence-only estimate (linear, free termini)
3841.62 sequence-only estimate (linear, free termini)
11.63 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
0.91 sequence-only estimate (linear, free termini)
-0.079 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 ug/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. neoformans (MIC 16 ug/mL). Also toxic to Devil Facial Tumour Disease (DFTD) cells ( Petrohilos et al., 2023 ). Upda
Evidence 2 Activity

Activity

MIC
Antifungal
16 ug/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against C. neoformans (MIC 16 ug/mL). Also toxic to Devil Facial Tumour Disease (DFTD) cells ( Petrohilos et al., 2023 ). Upda
Evidence 3 Activity

Activity

5% Hemolysis
Toxicity
1-500 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 1-500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidins in the Tasmanian devil (Sarcophilus harrisii). | Sci Rep | 2016