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Peptide record

TPDB11487

Antibacterial Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11487
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 33-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FKCRRWQWRWKKLGAKPVPIIYCNRRTGKCQRM
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C189H302N62O39S4
DEHS
R
4195.11
11.82
11
0
11
+11
3.00
-1.052
47.27
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
18115
4.32
8
Residue Composition
number
1
A
6
R
1
N
0
D
3
C
0
E
2
Q
2
G
0
H
2
I
1
L
5
K
1
M
1
F
2
P
0
S
1
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 6 N: 1 D: 0 C: 3 E: 0 Q: 2 G: 2 H: 0 I: 2 L: 1 K: 5 M: 1 F: 1 P: 2 S: 0 T: 1 W: 3 Y: 1 V: 1
Chemical Descriptors
33 reviewed residue count
C189H302N62O39S4 sequence-only estimate (linear, free termini)
4195.11 sequence-only estimate (linear, free termini)
11.82 sequence-only estimate (linear, free termini)
+11 sequence-only estimate (linear, free termini)
3.00 sequence-only estimate (linear, free termini)
-1.052 sequence-only estimate (linear, free termini)
Evidence Records 15 records
Evidence 1 Activity

Activity

IC50
Antibacterial
16 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus ATCC25923 (IC50 16 ug/ml), P. aeruginosa ATCC27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC53
Evidence 2 Activity

Activity

IC50
Antibacterial
32 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP

Other

active against S. aureus ATCC25923 (IC50 16 ug/ml), P. aeruginosa ATCC27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (I
Evidence 3 Activity

Activity

IC50
Antibacterial
32 µg/mL

Target

Escherichia coli O78

Source & Reference

dbAMP

Other

ive against S. aureus ATCC25923 (IC50 16 ug/ml), P. aeruginosa ATCC27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae
Evidence 4 Activity

Activity

IC50
Antibacterial
32 µg/mL

Target

S. pullorum CCVC533

Source & Reference

dbAMP

Other

23 (IC50 16 ug/ml), P. aeruginosa ATCC27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae HC2187 (IC50 32 ug/ml), and C. albica
Evidence 5 Activity

Activity

IC50
Antibacterial
16 µg/mL

Target

Enterobacter aerogenes HC2124

Source & Reference

dbAMP

Other

C27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae HC2187 (IC50 32 ug/ml), and C. albicans HC3150 (IC50 64 ug/ml).
Evidence 6 Activity

Activity

IC50
Antibacterial
32 µg/mL

Target

Klebsiella pneumoniae HC2187

Source & Reference

dbAMP

Other

IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae HC2187 (IC50 32 ug/ml), and C. albicans HC3150 (IC50 64 ug/ml).
Evidence 7 Activity

Activity

IC50
Antibacterial
64 µg/mL

Target

Candida albicans HC3150

Source & Reference

dbAMP

Other

32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae HC2187 (IC50 32 ug/ml), and C. albicans HC3150 (IC50 64 ug/ml).
Evidence 8 Activity

Activity

IC50
Antifungal
16 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against S. aureus ATCC25923 (IC50 16 ug/ml), P. aeruginosa ATCC27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC53
Evidence 9 Activity

Activity

IC50
Antifungal
32 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against S. aureus ATCC25923 (IC50 16 ug/ml), P. aeruginosa ATCC27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (I
Evidence 10 Activity

Activity

IC50
Antifungal
32 µg/mL

Target

Escherichia coli O78

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ive against S. aureus ATCC25923 (IC50 16 ug/ml), P. aeruginosa ATCC27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae
Evidence 11 Activity

Activity

IC50
Antifungal
32 µg/mL

Target

S. pullorum CCVC533

Source & Reference

dbAMP CAFPdb Antifungipept

Other

23 (IC50 16 ug/ml), P. aeruginosa ATCC27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae HC2187 (IC50 32 ug/ml), and C. albica
Evidence 12 Activity

Activity

IC50
Antifungal
16 µg/mL

Target

Enterobacter aerogenes HC2124

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C27853 (IC50 32 ug/ml), E. coli O78 (IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae HC2187 (IC50 32 ug/ml), and C. albicans HC3150 (IC50 64 ug/ml).
Evidence 13 Activity

Activity

IC50
Antifungal
32 µg/mL

Target

Klebsiella pneumoniae HC2187

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC50 32 ug/ml), S. pullorum CCVC533 (IC50 32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae HC2187 (IC50 32 ug/ml), and C. albicans HC3150 (IC50 64 ug/ml).
Evidence 14 Activity

Activity

IC50
Antifungal
64 µg/mL

Target

Candida albicans HC3150

Source & Reference

dbAMP CAFPdb Antifungipept

Other

32 ug/ml), E. aerogenes HC2124 (IC50 16 ug/ml), K. pneumoniae HC2187 (IC50 32 ug/ml), and C. albicans HC3150 (IC50 64 ug/ml).
Evidence 15 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Recombinant expression, purification, and antimicrobial activity of a novel hybrid antimicrobial peptide LFT33. | Appl Microbiol Biotechnol | 2012