TPDB

3D PDB MODEL

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TPDB ID TPDB11485

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb AVPpred-BWR ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLMSTLKDFGKTAAKEIAQSLLSTASCKLAKTC

FASTA

>TPDB11485|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=33
GLMSTLKDFGKTAAKEIAQSLLSTASCKLAKTC

Formula C147H255N39O47S3

Absent Amino Acids RNHPWYV

Common Amino Acids ALK

Mass 3417.05

PI 9.65

Basic Residues 5

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +3

Boman Index 4.08

Hydrophobicity 0.164

Aliphatic Index 86.06

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.66

Polar Residues 11

number

5

A

0

R

0

N

1

D

2

C

1

E

1

Q

2

G

0

H

1

I

5

L

5

K

1

M

1

F

0

P

4

S

4

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 5 R: 0 N: 0 D: 1 C: 2 E: 1 Q: 1 G: 2 H: 0 I: 1 L: 5 K: 5 M: 1 F: 1 P: 0 S: 4 T: 4 W: 0 Y: 0 V: 0

Length

33

Formula

C147H255N39O47S3

Mass

3417.05

PI

9.65

Net Charge

+3

Boman Index

4.08

Hydrophobicity

0.164

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against S. aureus ATCC2592, R. rhodochrous (Gram-poistive) and P. faecalis X29 (Gram-).

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against S. aureus ATCC2592, R. rhodochrous (Gram-poistive) and P. faecalis X29 (Gram-).

Evidence 3 Activity

Activity

Detail Source Activity Antiparasitic

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC2592, R. rhodochrous (Gram-poistive) and P. faecalis X29 (Gram-).

Evidence 4 Activity

Activity

Detail Source Activity Antiviral

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC2592, R. rhodochrous (Gram-poistive) and P. faecalis X29 (Gram-).

Evidence 5 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and characterization of antimicrobial peptides from skin of Amolops ricketti (Anura: Ranidae). | Peptides | 2012

Evidence 6 Activity

Activity

Activity Endpoint LD50

Detail Source Activity Toxicity

Activity Measurement 400 µg/mL

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.22100518]LD50>400 µg/ml against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2012 Jan 33(1):27-34.