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Peptide record

TPDB11480

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

33 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11480

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC

FASTA

>TPDB11480|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=33
GFLDTFKNLALNAAKSAGVSVLNSLSCKLFKTC

Formula C155H254N40O45S2

Absent Amino Acids REQHIMPWY

Common Amino Acids L

Mass 3462.08

PI 9.72

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 15

Net Charge +3

Boman Index -0.50

Hydrophobicity 0.509

Aliphatic Index 100.61

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.61

Polar Residues 11

number

Amino Acid Distribution

A: 4 R: 0 N: 3 D: 1 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 6 K: 4 M: 0 F: 3 P: 0 S: 4 T: 2 W: 0 Y: 0 V: 2

Length

Formula

C155H254N40O45S2

Mass

3462.08

9.72

Net Charge

Boman Index

-0.50

Hydrophobicity

0.509

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16.3 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.2 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

nst E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16.3 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.2 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

nst E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16.3 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.2 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

nst E. coli (MIC 16.3 ug/ml), S. aureus (MIC 8.2 ug/ml), B. subtilis (MIC 8.2 ug/ml), and C. albicans (MIC 4.1 ug/ml). Aslo histamine release.

Evidence 13 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 14 Activity

Activity

Activity Endpoint (15.2±4.9)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(15.2±4.9)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:17272268]Non-hemolytic activity against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.