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Peptide record

TPDB11478

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11478
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SIRDKIKTIAIDLAKSAGTGVLKTLICKLNKSC
Physicochemical Analysis
C153H277N43O45S2
EQHMFPWY
K
3503.26
10.27
7
2
13
+5
5.75
0.261
124.24
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
3.57
9
Residue Composition
number
3
A
1
R
1
N
2
D
2
C
0
E
0
Q
2
G
0
H
5
I
4
L
6
K
0
M
0
F
0
P
3
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 2 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 5 L: 4 K: 6 M: 0 F: 0 P: 0 S: 3 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
33
C153H277N43O45S2
3503.26
10.27
+5
5.75
0.261
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (
Evidence 3 Activity

Activity

MIC
Antibacterial
18.75 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (18.75 ug/ml). Updated 7/2020
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP DRAMP

Other

5923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (18.75 ug/ml). Updated 7/2020
Evidence 5 Activity

Activity

MIC
Antifungal
15 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC
Evidence 6 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (
Evidence 7 Activity

Activity

MIC
Antifungal
18.75 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (18.75 ug/ml). Updated 7/2020
Evidence 8 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (18.75 ug/ml). Updated 7/2020
Evidence 9 Activity

Activity

MIC
Antiparasitic
15 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC
Evidence 10 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (
Evidence 11 Activity

Activity

MIC
Antiparasitic
18.75 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (18.75 ug/ml). Updated 7/2020
Evidence 12 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

DRAMP

Other

5923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (18.75 ug/ml). Updated 7/2020
Evidence 13 Activity

Activity

MIC
Antiviral
15 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC
Evidence 14 Activity

Activity

MIC
Antiviral
12.5 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (
Evidence 15 Activity

Activity

MIC
Antiviral
18.75 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (18.75 ug/ml). Updated 7/2020
Evidence 16 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

DRAMP

Other

5923 (MIC 15 ug/ml), S. aureus ATCC43300 (MIC 12.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (18.75 ug/ml). Updated 7/2020
Evidence 17 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 18 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010