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Peptide record

TPDB11477

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard

33 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11477

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb AVPpred-BWR ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

SIRDKIKTIAIDLAKSAGMGILKTLICKLDKSC

FASTA

>TPDB11477|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=33
SIRDKIKTIAIDLAKSAGMGILKTLICKLDKSC

Formula C155H280N42O45S3

Absent Amino Acids NEQHFPWYV

Common Amino Acids IK

Mass 3548.36

PI 9.98

Basic Residues 7

Acidic Residues 3

Hydrophobic Residues 14

Net Charge +4

Boman Index 5.81

Hydrophobicity 0.348

Aliphatic Index 127.27

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.52

Polar Residues 7

number

Amino Acid Distribution

A: 3 R: 1 N: 0 D: 3 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 6 L: 4 K: 6 M: 1 F: 0 P: 0 S: 3 T: 2 W: 0 Y: 0 V: 0

Length

Formula

C155H280N42O45S3

Mass

3548.36

9.98

Net Charge

Boman Index

5.81

Hydrophobicity

0.348

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16.5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (15 ug/ml). Updated 7/2020

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ML-35P

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (15 ug/ml). Updated 7/2020

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16.5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (15 ug/ml). Updated 7/2020

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ML-35P

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (15 ug/ml). Updated 7/2020

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16.5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 18.75 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (15 ug/ml). Updated 7/2020

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ML-35P

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (15 ug/ml). Updated 7/2020

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 16.5 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 18.75 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (15 ug/ml). Updated 7/2020

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ML-35P

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus ATCC25923 (MIC 16.5 ug/ml), B. subtilis (MIC 18.75 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (15 ug/ml). Updated 7/2020

Evidence 13 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010

Evidence 14 Activity

Activity

Activity Endpoint (4.43±0.35)% Degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(4.43±0.35)% Degranulation | 50 | µg/mL | target cell: Rat mast cells

Target

Target Cell Rat mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010