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Peptide record

TPDB11468

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11468
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SIRDKIKTIAIDLAKSAGTGVLKTLICKLDKSC
Physicochemical Analysis
C153H276N42O46S2
NEQHMFPWY
K
3504.25
9.98
7
3
13
+4
6.56
0.261
124.24
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
3.57
8
Residue Composition
number
3
A
1
R
0
N
3
D
2
C
0
E
0
Q
2
G
0
H
5
I
4
L
6
K
0
M
0
F
0
P
3
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 3 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 5 L: 4 K: 6 M: 0 F: 0 P: 0 S: 3 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
33
C153H276N42O46S2
3504.25
9.98
+4
6.56
0.261
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.69 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5
Evidence 2 Activity

Activity

MIC
Antibacterial
9.38 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5.63 ug/ml). Updated 7/2020
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5.63 ug/ml). Updated 7/2020
Evidence 4 Activity

Activity

MIC
Antifungal
4.69 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5
Evidence 5 Activity

Activity

MIC
Antifungal
9.38 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5.63 ug/ml). Updated 7/2020
Evidence 6 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5.63 ug/ml). Updated 7/2020
Evidence 7 Activity

Activity

MIC
Antiparasitic
4.69 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5
Evidence 8 Activity

Activity

MIC
Antiparasitic
9.38 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5.63 ug/ml). Updated 7/2020
Evidence 9 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5.63 ug/ml). Updated 7/2020
Evidence 10 Activity

Activity

MIC
Antiviral
4.69 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5
Evidence 11 Activity

Activity

MIC
Antiviral
9.38 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5.63 ug/ml). Updated 7/2020
Evidence 12 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 4.69 ug/ml), B. subtilis (MIC 9.38 ug/ml), E. coli ML-35P (MIC 25 ug/ml), and C. albicans ATCC2002 (5.63 ug/ml). Updated 7/2020
Evidence 13 Activity

Activity

Hemolysis
[Ref:19778602]Show weak hemolytic activity against rabbit red cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Genomics. 2010 Jan 95(1):66-71.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

7% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 15 Activity

Activity

(14.33±4.86)% Degranulation
Toxicity
50 µg/mL
Cytotoxic
(14.33±4.86)% Degranulation | 50 | µg/mL | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:19778602]Show weak hemolytic activity against rabbit red cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Genomics. 2010 Jan 95(1):66-71.
Evidence 17 Hemolysis

Activity

[Ref:19778602]Show weak hemolytic activity against rabbit red cells
Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Genomics. 2010 Jan 95(1):66-71.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.