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Peptide record

TPDB11460

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11460
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC
Physicochemical Analysis
C146H252N40O46S2
REQHIMPWY
L
3367.97
9.72
4
1
14
+3
1.33
0.430
112.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.71
12
Residue Composition
number
4
A
0
R
3
N
1
D
2
C
0
E
0
Q
2
G
0
H
0
I
7
L
4
K
0
M
1
F
0
P
5
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 1 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 7 K: 4 M: 0 F: 1 P: 0 S: 5 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
33
C146H252N40O46S2
3367.97
9.72
+3
1.33
0.430
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 (MIC 12.5 uM), S. aureus NCTC 8325 (MIC 50 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 (MIC 12.5 uM), S. aureus NCTC 8325 (MIC 50 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 (MIC 12.5 uM), S. aureus NCTC 8325 (MIC 50 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 12.5 uM), S. aureus NCTC 8325 (MIC 50 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25922 (MIC 12.5 uM), S. aureus NCTC 8325 (MIC 50 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25922 (MIC 12.5 uM), S. aureus NCTC 8325 (MIC 50 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 7 Activity

Activity

LC50
Hemolysis
140 µM
[Ref.16621155] LC50=140 µM against human erythrocytes.

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides. 2006 Sep 27(9):2111-2117.##Mol Cell Proteomics. 2007 May 6(5):882-894.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
140 µM
Hemolytic Cytotoxic
50% Hemolysis | 140 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami. | Peptides | 2006
Evidence 9 Activity

Activity

12% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 128 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: de novo sequencing and analysis of tandem mass spectrometry data. | J Proteomics | 2012
Evidence 10 Activity

Activity

LC50
Toxicity
140 µM
Hemolytic
Hemolytic_activity: [Ref.16621155] LC50=140 µM against human erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2006 Sep 27(9):2111-2117.##Mol Cell Proteomics. 2007 May 6(5):882-894.
Evidence 11 Hemolysis

Activity

140 µM
LC50
[Ref.16621155] LC50=140 µM against human erythrocytes.
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides. 2006 Sep 27(9):2111-2117.##Mol Cell Proteomics. 2007 May 6(5):882-894.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.