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Peptide record

TPDB11455

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11455
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC
Physicochemical Analysis
C148H255N41O41S3
RNEPWY
G
3361.08
10.06
6
1
13
+4
3.49
0.455
103.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.72
7
Residue Composition
number
2
A
0
R
0
N
1
D
2
C
0
E
1
Q
6
G
1
H
2
I
4
L
5
K
1
M
1
F
0
P
2
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 2 E: 0 Q: 1 G: 6 H: 1 I: 2 L: 4 K: 5 M: 1 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
33
C148H255N41O41S3
3361.08
10.06
+4
3.49
0.455
Evidence Records 28 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
nhibitory activity against a range of Gram-negative and Gram-positive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3
Evidence 2 Activity

Activity

MIC
Antibacterial
6 µM

Target

Enterobacter cloacae HNTCC 5300

Source & Reference

dbAMP DRAMP

Other

ange of Gram-negative and Gram-positive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8
Evidence 3 Activity

Activity

MIC
Antibacterial
6 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

itive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epid
Evidence 4 Activity

Activity

MIC
Antibacterial
6 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP

Other

C25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. fae
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Staphylococcus aureus NCTC 8325 or MRSA

Source & Reference

dbAMP DRAMP

Other

5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP

Other

C 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATC
Evidence 7 Activity

Activity

MIC
Antibacterial
25 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

(MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
nhibitory activity against a range of Gram-negative and Gram-positive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3
Evidence 10 Activity

Activity

MIC
Antifungal
6 µM

Target

Enterobacter cloacae HNTCC 5300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ange of Gram-negative and Gram-positive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8
Evidence 11 Activity

Activity

MIC
Antifungal
6 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

itive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epid
Evidence 12 Activity

Activity

MIC
Antifungal
6 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. fae
Evidence 13 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Staphylococcus aureus NCTC 8325 or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC
Evidence 14 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATC
Evidence 15 Activity

Activity

MIC
Antifungal
25 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 17 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Escherichia coli ATCC25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
nhibitory activity against a range of Gram-negative and Gram-positive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3
Evidence 18 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Enterobacter cloacae HNTCC 5300

Source & Reference

DRAMP

Other

ange of Gram-negative and Gram-positive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8
Evidence 19 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

itive bacteria, including E. coli ATCC25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epid
Evidence 20 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

DRAMP

Other

C25922 (MIC 3 uM), E. cloacae HNTCC 5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. fae
Evidence 21 Activity

Activity

MIC
Antiparasitic
12.5-25 µM

Target

Staphylococcus aureus NCTC 8325 or MRSA

Source & Reference

DRAMP

Other

5300 (MIC 6 uM), P. aeruginosa ATCC 27853 (MIC 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC
Evidence 22 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

DRAMP

Other

C 6 uM), K. pneumoniae KK3 9904 (MIC 6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATC
Evidence 23 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

6 uM), S. aureus NCTC 8325 or MRSA (MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 24 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

DRAMP

Other

(MIC 12.5-25 uM), S. epidermidis RP62A (MIC 12.5 uM), E. faecalis ATCC 29212 (MIC 25 uM), C. albicans ATCC 90028 (MIC 100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 25 Activity

Activity

Hemolysis
[Ref.16413829] LD50=100 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Comp Biochem Physiol C Toxicol Pharmacol. 2006 May 143(1):42-49.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. | Comp Biochem Physiol C Toxicol Pharmacol | 2006
Evidence 27 Activity

Activity

LD50
Toxicity
100 µM
Hemolytic
Hemolytic_activity: [Ref.16413829] LD50=100 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Comp Biochem Physiol C Toxicol Pharmacol. 2006 May 143(1):42-49.
Evidence 28 Hemolysis

Activity

[Ref.16413829] LD50=100 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Comp Biochem Physiol C Toxicol Pharmacol. 2006 May 143(1):42-49.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.