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Peptide record

TPDB11448

Antibacterial Antifungal Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11448
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILDKLKEFGISAARGVAQSLLNTASCKLAKTC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C148H256N42O45S2
HMPWY
AL
3408.03
9.71
5
2
14
+3
0.74
0.300
106.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
0.04
9
Residue Composition
number
5
A
1
R
1
N
1
D
2
C
1
E
1
Q
3
G
0
H
2
I
5
L
4
K
0
M
1
F
0
P
3
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 1 C: 2 E: 1 Q: 1 G: 3 H: 0 I: 2 L: 5 K: 4 M: 0 F: 1 P: 0 S: 3 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
33 reviewed residue count
C148H256N42O45S2 sequence-only estimate (linear, free termini)
3408.03 sequence-only estimate (linear, free termini)
9.71 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.74 sequence-only estimate (linear, free termini)
0.300 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
50% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of diverse antimicrobial peptides in skin secretions of Chungan torrent frog Amolops chunganensis | Peptides | 2012
Evidence 2 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis