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Peptide record

TPDB11446

Antibacterial Antifungal Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11446
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
SILSTLKDVGISAIKSAGSGVLSTLLCKLNKNC
Physicochemical Analysis
C144H257N39O46S2
REQHMFPWY
LS
3334.98
9.72
4
1
13
+3
2.15
0.600
130.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
3.75
12
Residue Composition
number
2
A
0
R
2
N
1
D
2
C
0
E
0
Q
3
G
0
H
3
I
6
L
4
K
0
M
0
F
0
P
6
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 3 L: 6 K: 4 M: 0 F: 0 P: 0 S: 6 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
33
C144H257N39O46S2
3334.98
9.72
+3
2.15
0.600
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
100 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 1
Evidence 2 Activity

Activity

MIC
Antibacterial
100 µM

Target

E. faecium 091299

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 12.5 uM), Gram- P.aeruginosa CGMC
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 12.5 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneum
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

eus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 12.5 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloa
Evidence 5 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumoniae 08040724

Source & Reference

dbAMP

Other

50 uM), N. asteroides 201118 (MIC 12.5 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MI
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP

Other

0 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC
Evidence 7 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

P. faecalis X29

Source & Reference

dbAMP

Other

40724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.glabrata 090902

Source & Reference

dbAMP

Other

7 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
100 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 1
Evidence 10 Activity

Activity

MIC
Antifungal
100 µM

Target

E. faecium 091299

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 12.5 uM), Gram- P.aeruginosa CGMC
Evidence 11 Activity

Activity

MIC
Antifungal
50 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 12.5 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneum
Evidence 12 Activity

Activity

MIC
Antifungal
12.5 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

eus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 12.5 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloa
Evidence 13 Activity

Activity

MIC
Antifungal
>100 µM

Target

K.pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

50 uM), N. asteroides 201118 (MIC 12.5 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MI
Evidence 14 Activity

Activity

MIC
Antifungal
>100 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC
Evidence 15 Activity

Activity

MIC
Antifungal
6.3 µM

Target

P. faecalis X29

Source & Reference

dbAMP CAFPdb Antifungipept

Other

40724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

7 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 18 Activity

Activity

6% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
6% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 19 Activity

Activity

15% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
15% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 20 Activity

Activity

18% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
18% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 21 Activity

Activity

46% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
46% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 22 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.