Back to search

Peptide record

TPDB11443

Antibacterial Antifungal Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11443
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLRDKIKNVAIDVAKGAGTGVLKALLCQLDKSC
Physicochemical Analysis
C147H261N43O44S2
EHMFPWY
LK
3399.07
9.65
6
3
14
+3
6.39
0.248
121.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.68
6
Residue Composition
number
4
A
1
R
1
N
3
D
2
C
0
E
1
Q
4
G
0
H
2
I
5
L
5
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 3 C: 2 E: 0 Q: 1 G: 4 H: 0 I: 2 L: 5 K: 5 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
33
C147H261N43O44S2
3399.07
9.65
+3
6.39
0.248
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
200 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S.aureus ATCC 25923 (MIC 200 uM), E. faecium 091299 (IS) (MIC 100 uM), E.faecalis 981 (IS) (MIC 200 uM), N. asteroides 201
Evidence 2 Activity

Activity

MIC
Antibacterial
>400 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP

Other

IC >400 uM), K.Pneumoniae 08040724 (IS) (MIC >400 uM), E.cloacae CGMCC 1.57 (MIC 400 uM), E.coli ATCC 25922 (MIC >400 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C.glabrata 090902 (IS) (MIC 400 uM), C.albicans ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP

Other

2 (MIC >400 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C.glabrata 090902 (IS) (MIC 400 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 4 Activity

Activity

MIC
Antifungal
200 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S.aureus ATCC 25923 (MIC 200 uM), E. faecium 091299 (IS) (MIC 100 uM), E.faecalis 981 (IS) (MIC 200 uM), N. asteroides 201
Evidence 5 Activity

Activity

MIC
Antifungal
>400 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC >400 uM), K.Pneumoniae 08040724 (IS) (MIC >400 uM), E.cloacae CGMCC 1.57 (MIC 400 uM), E.coli ATCC 25922 (MIC >400 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C.glabrata 090902 (IS) (MIC 400 uM), C.albicans ATCC
Evidence 6 Activity

Activity

MIC
Antifungal
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

2 (MIC >400 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C.glabrata 090902 (IS) (MIC 400 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 7 Activity

Activity

32% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
32% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 8 Activity

Activity

54% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
54% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 9 Activity

Activity

90% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
90% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 10 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.