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Peptide record

TPDB11443

Antibacterial Antifungal Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11443
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLRDKIKNVAIDVAKGAGTGVLKALLCQLDKSC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C147H261N43O44S2
EHMFPWY
LK
3399.07
9.65
6
3
14
+3
0.81
0.248
121.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
0.04
6
Residue Composition
number
4
A
1
R
1
N
3
D
2
C
0
E
1
Q
4
G
0
H
2
I
5
L
5
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 3 C: 2 E: 0 Q: 1 G: 4 H: 0 I: 2 L: 5 K: 5 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
33 reviewed residue count
C147H261N43O44S2 sequence-only estimate (linear, free termini)
3399.07 sequence-only estimate (linear, free termini)
9.65 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.81 sequence-only estimate (linear, free termini)
0.248 sequence-only estimate (linear, free termini)
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
200 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S.aureus ATCC 25923 (MIC 200 uM), E. faecium 091299 (IS) (MIC 100 uM), E.faecalis 981 (IS) (MIC 200 uM), N. asteroides 201
Evidence 2 Activity

Activity

MIC
Antibacterial
>400 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP

Other

IC >400 uM), K.Pneumoniae 08040724 (IS) (MIC >400 uM), E.cloacae CGMCC 1.57 (MIC 400 uM), E.coli ATCC 25922 (MIC >400 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C.glabrata 090902 (IS) (MIC 400 uM), C.albicans ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP

Other

2 (MIC >400 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C.glabrata 090902 (IS) (MIC 400 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 4 Activity

Activity

MIC
Antifungal
200 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S.aureus ATCC 25923 (MIC 200 uM), E. faecium 091299 (IS) (MIC 100 uM), E.faecalis 981 (IS) (MIC 200 uM), N. asteroides 201
Evidence 5 Activity

Activity

MIC
Antifungal
>400 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC >400 uM), K.Pneumoniae 08040724 (IS) (MIC >400 uM), E.cloacae CGMCC 1.57 (MIC 400 uM), E.coli ATCC 25922 (MIC >400 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C.glabrata 090902 (IS) (MIC 400 uM), C.albicans ATCC
Evidence 6 Activity

Activity

MIC
Antifungal
>400 µM

Target

C.albicans ATCC10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

2 (MIC >400 uM), P. faecalis X29 (IS) (MIC 12.5 uM), C.glabrata 090902 (IS) (MIC 400 uM), C.albicans ATCC10231 (MIC>400 uM). IS= Isolated strain.
Evidence 7 Activity

Activity

32% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
32% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 8 Activity

Activity

54% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
54% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 9 Activity

Activity

90% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
90% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae). | Biochimie | 2013
Evidence 10 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.