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Peptide record

TPDB11440

Antibacterial Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11440
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFMDTAKNVAKNVAKNVAVTLLDKLRCKVTGGC
Physicochemical Analysis
C149H258N44O44S3
EQHIPSWY
KV
3466.14
10.06
6
2
14
+4
6.08
0.136
91.52
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.61
8
Residue Composition
number
4
A
1
R
3
N
2
D
2
C
0
E
0
Q
3
G
0
H
0
I
3
L
5
K
1
M
1
F
0
P
0
S
3
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 4 R: 1 N: 3 D: 2 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 5 M: 1 F: 1 P: 0 S: 0 T: 3 W: 0 Y: 0 V: 5
Chemical Descriptors
33
C149H258N44O44S3
3466.14
10.06
+4
6.08
0.136
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
100 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 6
Evidence 2 Activity

Activity

MIC
Antibacterial
100 µM

Target

E. faecium 091299

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 6.3 uM), Gram- P.aeruginosa CGMCC
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 6.3 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumo
Evidence 4 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

eus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 6.3 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloa
Evidence 5 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumoniae 08040724

Source & Reference

dbAMP

Other

C 50 uM), N. asteroides 201118 (MIC 6.3 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MI
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP

Other

0 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC
Evidence 7 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

P. faecalis X29

Source & Reference

dbAMP

Other

40724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.glabrata 090902

Source & Reference

dbAMP

Other

7 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
100 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 6
Evidence 10 Activity

Activity

MIC
Antifungal
100 µM

Target

E. faecium 091299

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 6.3 uM), Gram- P.aeruginosa CGMCC
Evidence 11 Activity

Activity

MIC
Antifungal
50 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 6.3 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumo
Evidence 12 Activity

Activity

MIC
Antifungal
6.3 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

eus ATCC 25923 (MIC 100 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 50 uM), N. asteroides 201118 (MIC 6.3 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloa
Evidence 13 Activity

Activity

MIC
Antifungal
>100 µM

Target

K.pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C 50 uM), N. asteroides 201118 (MIC 6.3 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MI
Evidence 14 Activity

Activity

MIC
Antifungal
>100 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 (MIC >100 uM), K.pneumoniae 08040724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC
Evidence 15 Activity

Activity

MIC
Antifungal
3.1 µM

Target

P. faecalis X29

Source & Reference

dbAMP CAFPdb Antifungipept

Other

40724 (MIC >100 uM), E.cloacae CGMCC 1.57 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

7 (MIC >100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 3.1 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 18 Activity

Activity

5% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
5% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014