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Peptide record

TPDB11438

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

33 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11438

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GRKSDCFRKNGFCAFLKCPYLTLISGLCSFHLC

FASTA

>TPDB11438|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=33
GRKSDCFRKNGFCAFLKCPYLTLISGLCSFHLC

Formula C167H259N45O42S5

Absent Amino Acids EQMWV

Common Amino Acids CL

Mass 3729.47

PI 8.82

Basic Residues 6

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +4

Boman Index -1.73

Hydrophobicity 0.330

Aliphatic Index 73.94

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1740

Absorbance 280nm 46.66

Polar Residues 11

number

Amino Acid Distribution

A: 1 R: 2 N: 1 D: 1 C: 5 E: 0 Q: 0 G: 3 H: 1 I: 1 L: 5 K: 3 M: 0 F: 4 P: 1 S: 3 T: 1 W: 0 Y: 1 V: 0

Length

Formula

C167H259N45O42S5

Mass

3729.47

8.82

Net Charge

Boman Index

-1.73

Hydrophobicity

0.330

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhim

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism B. avium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. j

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-m

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism S. enteriditis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

tive against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-multocida (MIC >16 ug/ml), M. g

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 16 ug/ml) (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism C. jejuni

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 16 ug/ml) ( Evans et al., 1995 . Also

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism M. gallisepticum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 16 ug/ml) ( Evans et al., 1995 . Also, S. aureus. Updated 7/2021, Jan2023 12/2024.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhim

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism B. avium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. j

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-m

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism S. enteriditis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism C. jejuni

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism M. gallisepticum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 16 ug/ml) ( Evans et al., 1995 . Also, S. aureus. Updated 7/2021, Jan2023 12/2024.

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhim

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16 µg/mL

Target

Target Organism B. avium

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. j

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-m

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism S. enteriditis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism C. jejuni

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16 µg/mL

Target

Target Organism M. gallisepticum

Source & Reference

Database Source DRAMP

Other

Evidence Text

/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 16 ug/ml) ( Evans et al., 1995 . Also, S. aureus. Updated 7/2021, Jan2023 12/2024.

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 16 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhim

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 16 µg/mL

Target

Target Organism B. avium

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. j

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 16 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against C. albicans (MIC 16 ug/ml), B. avium (MIC 16 ug/ml), E. coli (MIC 16 ug/ml), S. enteriditis (MIC 8 ug/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-m

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µg/mL

Target

Target Organism S. enteriditis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µg/mL

Target

Target Organism C. jejuni

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 16 µg/mL

Target

Target Organism M. gallisepticum

Source & Reference

Database Source DRAMP

Other

Evidence Text

/ml), S. typhimurium (MIC 8 ug/ml), C. jejuni (MIC 4 ug/ml), P-multocida (MIC >16 ug/ml), M. gallisepticum (MIC 16 ug/ml) ( Evans et al., 1995 . Also, S. aureus. Updated 7/2021, Jan2023 12/2024.