Back to search

Peptide record

TPDB11436

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11436
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GVLDTFKDVAIGVAKGAGTGVLKALLCKLDKSC
Physicochemical Analysis
C146H252N38O43S2
RNEQHMPWY
GLK
3291.96
9.02
5
3
15
+2
3.98
0.639
118.18
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.80
5
Residue Composition
number
4
A
0
R
0
N
3
D
2
C
0
E
0
Q
5
G
0
H
1
I
5
L
5
K
0
M
1
F
0
P
1
S
2
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 3 C: 2 E: 0 Q: 0 G: 5 H: 0 I: 1 L: 5 K: 5 M: 0 F: 1 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 4
Chemical Descriptors
33
C146H252N38O43S2
3291.96
9.02
+2
3.98
0.639
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
60 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC2592 (MIC 60 uM), R. rhodochrous X15 (IS) (MIC 30 uM), and P. faecalis X29 (IS) (MIC 15 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
60 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC2592 (MIC 60 uM), R. rhodochrous X15 (IS) (MIC 30 uM), and P. faecalis X29 (IS) (MIC 15 uM).
Evidence 3 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus ATCC2592 (MIC 60 uM), R. rhodochrous X15 (IS) (MIC 30 uM), and P. faecalis X29 (IS) (MIC 15 uM).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>480 µM
Hemolytic Cytotoxic
50% Hemolysis | >480 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii | Biochimie | 2012
Evidence 5 Activity

Activity

LD50
Toxicity
480 µM
Hemolytic
Hemolytic_activity: [Ref.22426384] LD50>480 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2012 Jun 94(6):1317-1326.