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Peptide record

TPDB11430

Antibacterial Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11430
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 33-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SILDKIKNVALGVARGAGTGILKALLCKLDKSC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C148H266N42O42S2
EQHMFPWY
L
3370.12
10.06
6
2
15
+4
0.31
0.561
136.06
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
0.04
6
Residue Composition
number
4
A
1
R
1
N
2
D
2
C
0
E
0
Q
4
G
0
H
3
I
6
L
5
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 2 C: 2 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 6 K: 5 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
33 reviewed residue count
C148H266N42O42S2 sequence-only estimate (linear, free termini)
3370.12 sequence-only estimate (linear, free termini)
10.06 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.31 sequence-only estimate (linear, free termini)
0.561 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.8 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC2592 (MIC 3.8 uM), B. licheniformis X39 (IS) (MIC 3.8 uM), S. carnosus KHS (IS) (MIC 1.9 uM), R. rhodochrou
Evidence 2 Activity

Activity

MIC
Antibacterial
30 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

S) (MIC 3.8 uM), S. carnosus KHS (IS) (MIC 1.9 uM), R. rhodochrous X15 (IS) (MIC 1.9 uM), E. coli ATCC 25922 (MIC 30 uM), S. rubidaea X01 (IS) (MIC 60 uM), P. aeruginosa 1.50 (IS) (MIC 30 uM), and P. faecalis X
Evidence 3 Activity

Activity

MIC
Antifungal
3.8 µM

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC2592 (MIC 3.8 uM), B. licheniformis X39 (IS) (MIC 3.8 uM), S. carnosus KHS (IS) (MIC 1.9 uM), R. rhodochrou
Evidence 4 Activity

Activity

MIC
Antifungal
30 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S) (MIC 3.8 uM), S. carnosus KHS (IS) (MIC 1.9 uM), R. rhodochrous X15 (IS) (MIC 1.9 uM), E. coli ATCC 25922 (MIC 30 uM), S. rubidaea X01 (IS) (MIC 60 uM), P. aeruginosa 1.50 (IS) (MIC 30 uM), and P. faecalis X
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
480 µM
Hemolytic Cytotoxic
50% Hemolysis | 480 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii | Biochimie | 2012
Evidence 6 Activity

Activity

LD50
Toxicity
480 µM
Hemolytic
Hemolytic_activity: [Ref.22426384] LD50=480 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2012 Jun 94(6):1317-1326.