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Peptide record

TPDB11423

Antibacterial Anticancer Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11423
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFWSSVWDGAKNVGTAIIKNAKVCVYAVCVSHK
Physicochemical Analysis
C161H249N43O43S2
REQLMP
V
3539.13
9.58
5
1
16
+3
0.42
0.379
88.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12615
356.44
9
Residue Composition
number
4
A
0
R
2
N
1
D
2
C
0
E
0
Q
3
G
1
H
2
I
0
L
4
K
0
M
1
F
0
P
3
S
1
T
2
W
1
Y
6
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 1 C: 2 E: 0 Q: 0 G: 3 H: 1 I: 2 L: 0 K: 4 M: 0 F: 1 P: 0 S: 3 T: 1 W: 2 Y: 1 V: 6
Chemical Descriptors
33
C161H249N43O43S2
3539.13
9.58
+3
0.42
0.379
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.125 µM

Target

M. luteus

Source & Reference

NA

Other

Active against Gram+ M. luteus (MIC 0.125 uM), B. subtilis (0.062 uM), B. licheniformis (0.125 uM), S. aureus 209P (2 uM), S. aureus AT
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

Escherichia coli ML-35p

Source & Reference

NA

Other

C 29213 (2 uM), Rhodococcus sp. (0.125 uM), Gram- bacteria E. coli BL21 (DE3) (MIC 2 uM), E. coli ML-35p (MIC 16 uM), A. baumannii (MIC 32 uM), P. aeruginosa PAO1 (32 uM). At 16 uM, it didn't inhibit B-mega
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

A. baumannii

Source & Reference

NA

Other

sp. (0.125 uM), Gram- bacteria E. coli BL21 (DE3) (MIC 2 uM), E. coli ML-35p (MIC 16 uM), A. baumannii (MIC 32 uM), P. aeruginosa PAO1 (32 uM). At 16 uM, it didn't inhibit B-megaterium.
Evidence 4 Activity

Activity

MIC
Antifungal
0.125 µM

Target

M. luteus

Source & Reference

Antifungipept

Other

Active against Gram+ M. luteus (MIC 0.125 uM), B. subtilis (0.062 uM), B. licheniformis (0.125 uM), S. aureus 209P (2 uM), S. aureus AT
Evidence 5 Activity

Activity

MIC
Antifungal
16 µM

Target

Escherichia coli ML-35p

Source & Reference

Antifungipept

Other

C 29213 (2 uM), Rhodococcus sp. (0.125 uM), Gram- bacteria E. coli BL21 (DE3) (MIC 2 uM), E. coli ML-35p (MIC 16 uM), A. baumannii (MIC 32 uM), P. aeruginosa PAO1 (32 uM). At 16 uM, it didn't inhibit B-mega
Evidence 6 Activity

Activity

MIC
Antifungal
32 µM

Target

A. baumannii

Source & Reference

Antifungipept

Other

sp. (0.125 uM), Gram- bacteria E. coli BL21 (DE3) (MIC 2 uM), E. coli ML-35p (MIC 16 uM), A. baumannii (MIC 32 uM), P. aeruginosa PAO1 (32 uM). At 16 uM, it didn't inhibit B-megaterium.
Evidence 7 Activity

Activity

70% Killing
Toxicity
32 µM
Cytotoxic
70% Killing | 32 | µM | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptides from the Arctic Polychaeta Nicomache minor Provide New Molecular Insight into Biological Role of the BRICHOS Domain. | Mar Drugs | 2018
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
50% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptides from the Arctic Polychaeta Nicomache minor Provide New Molecular Insight into Biological Role of the BRICHOS Domain. | Mar Drugs | 2018
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2018 Oct 23 16(11):401.