Back to search

Peptide record

TPDB11422

dermaseptin-PD-2 Antibacterial Anticancer Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11422
dermaseptin-PD-2
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
GMWSKIKNAGKAAAKAAAKAAGKAALDAVSEAI
Physicochemical Analysis
C139H237N41O41S1
RCQHFPTY
A
3170.72
10.54
6
2
19
+4
4.50
0.142
83.64
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
173.46
3
Residue Composition
number
13
A
0
R
1
N
1
D
0
C
1
E
0
Q
3
G
0
H
2
I
1
L
6
K
1
M
0
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 13 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 1 K: 6 M: 1 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
33
C139H237N41O41S1
3170.72
10.54
+4
4.50
0.142
Free
L
Linear
Free
Antimicrobial
phyllomedusine leaf frogs,Pachymedusa dacnicolor
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Strongly active against E. coli (MIC 5 uM), S. aureus (MIC 5 uM), C. albicans (10 uM), P. aeruginosa (MIC 2.5 uM). MBC are higher
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Strongly active against E. coli (MIC 5 uM), S. aureus (MIC 5 uM), C. albicans (10 uM), P. aeruginosa (MIC 2.5 uM). MBC are higher
Evidence 3 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Strongly active against E. coli (MIC 5 uM), S. aureus (MIC 5 uM), C. albicans (10 uM), P. aeruginosa (MIC 2.5 uM). MBC are higher
Evidence 4 Activity

Activity

IC50
IC50 = 6.43 µM
Anticancer
6.43 µM

Target

Lung Cancer
H-157
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2016

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 5 Activity

Activity

IC50
IC50 = 3.17 µM
Anticancer
3.17 µM

Target

Prostate Cancer
PC-3
Prostate

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2016
Evidence 6 Activity

Activity

IC50
IC50 = 13.43 µM
Anticancer
13.43 µM

Target

Brain Tumor
U251-MG
Brain

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2016
Evidence 7 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Strongly active against E. coli (MIC 5 uM), S. aureus (MIC 5 uM), C. albicans (10 uM), P. aeruginosa (MIC 2.5 uM). MBC are higher
Evidence 8 Activity

Activity

MIC
Antifungal
5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Strongly active against E. coli (MIC 5 uM), S. aureus (MIC 5 uM), C. albicans (10 uM), P. aeruginosa (MIC 2.5 uM). MBC are higher
Evidence 9 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Strongly active against E. coli (MIC 5 uM), S. aureus (MIC 5 uM), C. albicans (10 uM), P. aeruginosa (MIC 2.5 uM). MBC are higher
Evidence 10 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor. | Toxins (Basel) | 2016
Evidence 11 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxins (Basel). 2016 May 12 8(5):144.