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Peptide record

TPDB11418

Antibacterial Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB11418
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
SPPQAMGFPPQVNVEHYIPASYSVAALTVTEEE
Physicochemical Analysis
C160H240N38O52S1
RDCKW
P
3559.95
3.79
1
4
14
-4
9.04
-0.167
70.91
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
2980
83.71
10
Residue Composition
number
4
A
0
R
1
N
0
D
0
C
4
E
2
Q
1
G
1
H
1
I
1
L
0
K
1
M
1
F
5
P
3
S
2
T
0
W
2
Y
4
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 0 E: 4 Q: 2 G: 1 H: 1 I: 1 L: 1 K: 0 M: 1 F: 1 P: 5 S: 3 T: 2 W: 0 Y: 2 V: 4
Chemical Descriptors
33
C160H240N38O52S1
3559.95
3.79
-4
9.04
-0.167
Evidence Records 4 records
Evidence 1 Activity

Activity

6.89% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
6.89% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 2 Activity

Activity

7.55% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
7.55% Cytotoxicity | 100 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 3 Activity

Activity

9.86% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
9.86% Cytotoxicity | 100 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018
Evidence 4 Activity

Activity

10.73% Degranulation
Toxicity
100 µg/mL
Cytotoxic
10.73% Degranulation | 100 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality. | J Med Chem | 2018