TPDB

3D PDB MODEL

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TPDB ID TPDB11414

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

NPEKALEKLIAIQKAIKGMLNGWFTGVGFRRKR

FASTA

>TPDB11414|Antibacterial;Anticancer;Toxicity|length=33
NPEKALEKLIAIQKAIKGMLNGWFTGVGFRRKR

Formula C172H285N51O42S1

Absent Amino Acids DCHSY

Common Amino Acids K

Mass 3771.53

PI 11.58

Basic Residues 8

Acidic Residues 2

Hydrophobic Residues 14

Net Charge +6

Boman Index 6.08

Hydrophobicity -0.403

Aliphatic Index 88.79

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 145.83

Polar Residues 4

number

3

A

3

R

2

N

0

D

0

C

2

E

1

Q

4

G

0

H

3

I

3

L

5

K

1

M

2

F

1

P

0

S

1

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 3 R: 3 N: 2 D: 0 C: 0 E: 2 Q: 1 G: 4 H: 0 I: 3 L: 3 K: 5 M: 1 F: 2 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 1

Length

33

Formula

C172H285N51O42S1

Mass

3771.53

PI

11.58

Net Charge

+6

Boman Index

6.08

Hydrophobicity

-0.403

Evidence 1 Activity

Activity

Activity Endpoint 1.97% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1.97% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Highly potent antimicrobial modified peptides derived from the Acinetobacter baumannii phage endolysin LysAB2. | Sci Rep | 2017

Evidence 2 Activity

Activity

Activity Endpoint <10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<10% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Highly potent antimicrobial modified peptides derived from the Acinetobacter baumannii phage endolysin LysAB2. | Sci Rep | 2017

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Highly potent antimicrobial modified peptides derived from the Acinetobacter baumannii phage endolysin LysAB2. | Sci Rep | 2017

Evidence 4 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1.97 %

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: 1.97% Hemolysis=4µM <10% Hemolysis=256µM | Cytotoxicity: HaCat: Not active up to 200 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Sci Rep. 2017 Sep 13 7(1):11477.