TPDB11406

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism M. canis IP 1194

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii I

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism T. rubrum IP 1400-82

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae I

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 125 µg/mL

Target

Target Organism A. fumigatus IP 1025-70

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism A. simii IP 1063-74

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 60 µg/mL

Target

Target Organism A. caviae IP 67-16 T

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli IP 76-24

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoforman

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.7 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

e IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism N. brasiliensis IP 16-80

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

i IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism C. neoformans IP 960-67 or IP 962-67

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

liensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 12 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 =1.24±0.23 µM

Detail Source Activity Anticancer

Activity Measurement 1.24

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay LDH leakage assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 13 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 =0.31±0.15 µM

Detail Source Activity Anticancer

Activity Measurement 0.31

Target

Cancer Type Prostate Cancer

Cell Line LNCaP

Tissue Affected Prostate

Assay & Model

Assay LDH leakage assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 14 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 =0.91±0.04 µM

Detail Source Activity Anticancer

Activity Measurement 0.91

Target

Cancer Type Liver Cancer

Cell Line DU-145

Tissue Affected Prostate

Assay & Model

Assay LDH leakage assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 15 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 =8.06±0.50 µM

Detail Source Activity Anticancer

Activity Measurement 8.06

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-231

Tissue Affected Breast

Assay & Model

Assay LDH leakage assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 16 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 =2.57±0.75 µM

Detail Source Activity Anticancer

Activity Measurement 2.57

Target

Cancer Type Lymphoma Cancer

Cell Line Raji

Tissue Affected Blood

Assay & Model

Assay LDH leakage assay

Testing Time 24-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µg/mL

Target

Target Organism M. canis IP 1194

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii I

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism T. rubrum IP 1400-82

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae I

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 125 µg/mL

Target

Target Organism A. fumigatus IP 1025-70

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-2

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism A. simii IP 1063-74

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 60 µg/mL

Target

Target Organism A. caviae IP 67-16 T

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

C 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli IP 76-24

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoforman

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.7 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

e IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism N. brasiliensis IP 16-80

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

i IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism C. neoformans IP 960-67 or IP 962-67

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

liensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µg/mL

Target

Target Organism M. canis IP 1194

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii I

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism T. rubrum IP 1400-82

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae I

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 125 µg/mL

Target

Target Organism A. fumigatus IP 1025-70

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against M. canis IP 1194 (MIC 10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-2

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism A. simii IP 1063-74

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

10 ug/ml), T. rubrum IP 1400-82 (MIC 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 60 µg/mL

Target

Target Organism A. caviae IP 67-16 T

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

C 15 ug/ml), A. fumigatus IP 1025-70 (MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Escherichia coli IP 76-24

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

(MIC 125 ug/ml), A. simii IP 1063-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.1 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

-74 (MIC 30 ug/ml), A. caviae IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoforman

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.7 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

e IP 67-16 T (MIC 60 ug/ml), E. coli IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism N. brasiliensis IP 16-80

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

i IP 76-24 (MIC 15 ug/ml), P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism C. neoformans IP 960-67 or IP 962-67

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

(MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

liensis IP 16-80 (MIC 30 ug/ml), C. neoformans IP 960-67 or IP 962-67 (MIC 15 ug/ml), and C. albicans (MIC 15 ug/ml).

Evidence 39 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >500 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >500 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini. | Biochemistry | 2006

Evidence 40 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 1.09±0.56 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 1.09±0.56 | µM | target cell: LB-EBV

Target

Target Cell LB-EBV

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. | PLoS One | 2012

Evidence 41 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 1.80±0.40 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 1.80±0.40 | µM | target cell: Human corneal fibroblasts HTK

Target

Target Cell Human corneal fibroblasts HTK

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. | PLoS One | 2012

Evidence 42 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 0.38±0.05 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 0.38±0.05 | µM | target cell: Human prostatic cells PNT1A

Target

Target Cell Human prostatic cells PNT1A

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. | PLoS One | 2012

Evidence 43 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Human stromal prostate fibroblasts G1947

Target

Target Cell Human stromal prostate fibroblasts G1947

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. | PLoS One | 2012

Evidence 44 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Human skin fibroblasts

Target

Target Cell Human skin fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. | PLoS One | 2012

Evidence 45 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >250 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | >250 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides. | Biochim Biophys Acta | 2009

Evidence 46 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:8306981]Lack hemolytic activity against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Eur J Biochem 1994, 219 (1-2):145-154.##Proc Natl Acad Sci U S A. 1992 Nov 15 89(22):10960-10963.##Cell Mol Neurobiol. 1994 Apr 14(2):133-157.##Cell Mol Neurobiol. 1995 Aug 15(4):465-493.