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Peptide record

TPDB11400

Antibacterial Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11400
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
SFLDKFKDVAIGVAKGAGTGVLKALLCKLDNSC
Physicochemical Analysis
C151H253N39O44S2
REQHMPWY
LK
3383.02
9.02
5
3
15
+2
3.18
0.500
109.39
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
3.69
6
Residue Composition
number
4
A
0
R
1
N
3
D
2
C
0
E
0
Q
4
G
0
H
1
I
5
L
5
K
0
M
2
F
0
P
2
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 3 C: 2 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 5 K: 5 M: 0 F: 2 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
33
C151H253N39O44S2
3383.02
9.02
+2
3.18
0.500
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
150 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S.aureus ATCC 25923 (MIC 150 uM), E.faecalis 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (M
Evidence 2 Activity

Activity

MIC
Antibacterial
9.4 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

Active against S.aureus ATCC 25923 (MIC 150 uM), E.faecalis 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (MIC 150 uM), K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 2
Evidence 3 Activity

Activity

MIC
Antibacterial
75 µM

Target

Klebsiella pneumoniae 08040724

Source & Reference

dbAMP

Other

981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (MIC 150 uM), K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922 (MIC 18.8 uM), C.albicans ATCC 10231 (MIC 150 uM), and C. glabrata 09
Evidence 4 Activity

Activity

MIC
Antibacterial
18.8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

8 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (MIC 150 uM), K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922 (MIC 18.8 uM), C.albicans ATCC 10231 (MIC 150 uM), and C. glabrata 090902 (MIC 75 uM). Updated 5/2019
Evidence 5 Activity

Activity

MIC
Antibacterial
150 µM

Target

C.albicans ATCC 10231

Source & Reference

dbAMP

Other

1.50 (MIC 150 uM), K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922 (MIC 18.8 uM), C.albicans ATCC 10231 (MIC 150 uM), and C. glabrata 090902 (MIC 75 uM). Updated 5/2019 7/2021
Evidence 6 Activity

Activity

MIC
Antibacterial
75 µM

Target

C. glabrata 090902

Source & Reference

dbAMP

Other

24 (MIC 75 uM), E. coli ATCC 25922 (MIC 18.8 uM), C.albicans ATCC 10231 (MIC 150 uM), and C. glabrata 090902 (MIC 75 uM). Updated 5/2019 7/2021
Evidence 7 Activity

Activity

MIC
Antifungal
150 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S.aureus ATCC 25923 (MIC 150 uM), E.faecalis 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (M
Evidence 8 Activity

Activity

MIC
Antifungal
9.4 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S.aureus ATCC 25923 (MIC 150 uM), E.faecalis 981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (MIC 150 uM), K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 2
Evidence 9 Activity

Activity

MIC
Antifungal
75 µM

Target

Klebsiella pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

981 (inactive), N. asteroides 201118 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (MIC 150 uM), K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922 (MIC 18.8 uM), C.albicans ATCC 10231 (MIC 150 uM), and C. glabrata 09
Evidence 10 Activity

Activity

MIC
Antifungal
18.8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

8 (MIC 9.4 uM), P.aeruginosa CGMCC 1.50 (MIC 150 uM), K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922 (MIC 18.8 uM), C.albicans ATCC 10231 (MIC 150 uM), and C. glabrata 090902 (MIC 75 uM). Updated 5/2019
Evidence 11 Activity

Activity

MIC
Antifungal
150 µM

Target

C.albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

1.50 (MIC 150 uM), K. pneumoniae 08040724 (MIC 75 uM), E. coli ATCC 25922 (MIC 18.8 uM), C.albicans ATCC 10231 (MIC 150 uM), and C. glabrata 090902 (MIC 75 uM). Updated 5/2019 7/2021
Evidence 12 Activity

Activity

MIC
Antifungal
75 µM

Target

C. glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

24 (MIC 75 uM), E. coli ATCC 25922 (MIC 18.8 uM), C.albicans ATCC 10231 (MIC 150 uM), and C. glabrata 090902 (MIC 75 uM). Updated 5/2019 7/2021
Evidence 13 Activity

Activity

58.5% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
58.5% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 14 Activity

Activity

28.1% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
28.1% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 15 Activity

Activity

8.4% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
8.4% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 16 Activity

Activity

4.3% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
4.3% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
0% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017