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Peptide record

TPDB11399

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

33 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11399

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

SVLGTVKDLLIGAGKSAAQSVLTTLSCKLSNSC

FASTA

>TPDB11399|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=33
SVLGTVKDLLIGAGKSAAQSVLTTLSCKLSNSC

Formula C139H246N38O47S2

Absent Amino Acids REHMFPWY

Common Amino Acids LS

Mass 3265.83

PI 9.08

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +2

Boman Index 1.98

Hydrophobicity 0.606

Aliphatic Index 118.18

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.83

Polar Residues 13

number

Amino Acid Distribution

A: 3 R: 0 N: 1 D: 1 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 6 K: 3 M: 0 F: 0 P: 0 S: 6 T: 3 W: 0 Y: 0 V: 3

Length

Formula

C139H246N38O47S2

Mass

3265.83

9.08

Net Charge

Boman Index

1.98

Hydrophobicity

0.606

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), a

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.aureus MRSA-inactive

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism C.albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), a

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism S.aureus MRSA-inactive

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism C.albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), a

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism S.aureus MRSA-inactive

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism C.albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), a

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism S.aureus MRSA-inactive

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

against E. coli (MIC 50 uM), S. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism C.albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

. aureus (MIC 25 uM), S.aureus MRSA-inactive (MIC >100 uM), B.subtilis (MIC >100 uM), and C.albicans (MIC >100 uM).