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Peptide record

TPDB11394

Antibacterial Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11394
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
SIMSTLKQFGISAIKGAAQNVLGVLSCKIAKTC
Physicochemical Analysis
C148H258N40O43S3
RDEHPWY
AIKS
3382.10
10.17
4
0
15
+4
1.07
0.691
112.42
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
3.70
11
Residue Composition
number
4
A
0
R
1
N
0
D
2
C
0
E
2
Q
3
G
0
H
4
I
3
L
4
K
1
M
1
F
0
P
4
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 2 G: 3 H: 0 I: 4 L: 3 K: 4 M: 1 F: 1 P: 0 S: 4 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
33
C148H258N40O43S3
3382.10
10.17
+4
1.07
0.691
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 25 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 25 uM), N. asteroides 201118 (MIC 3.
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

E. faecium 091299

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 25 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 25 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 25 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 25 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.Pneumo
Evidence 4 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

ureus ATCC 25923 (MIC 25 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 25 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.Pneumoniae 08040724 (MIC >100 uM), E. clo
Evidence 5 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.Pneumoniae 08040724

Source & Reference

dbAMP

Other

C 25 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.Pneumoniae 08040724 (MIC >100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MI
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP

Other

0 (MIC >100 uM), K.Pneumoniae 08040724 (MIC >100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC
Evidence 7 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

P. faecalis X29

Source & Reference

dbAMP

Other

40724 (MIC >100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.glabrata 090902

Source & Reference

dbAMP

Other

57 (MIC 100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 25 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 25 uM), N. asteroides 201118 (MIC 3.
Evidence 10 Activity

Activity

MIC
Antifungal
25 µM

Target

E. faecium 091299

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 25 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 25 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC
Evidence 11 Activity

Activity

MIC
Antifungal
25 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 25 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 25 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.Pneumo
Evidence 12 Activity

Activity

MIC
Antifungal
3.1 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ureus ATCC 25923 (MIC 25 uM), E. faecium 091299 (MIC 25 uM), E. faecalis 981 (MIC 25 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.Pneumoniae 08040724 (MIC >100 uM), E. clo
Evidence 13 Activity

Activity

MIC
Antifungal
>100 µM

Target

K.Pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C 25 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K.Pneumoniae 08040724 (MIC >100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MI
Evidence 14 Activity

Activity

MIC
Antifungal
>100 µM

Target

E.coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 (MIC >100 uM), K.Pneumoniae 08040724 (MIC >100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC
Evidence 15 Activity

Activity

MIC
Antifungal
6.3 µM

Target

P. faecalis X29

Source & Reference

dbAMP CAFPdb Antifungipept

Other

40724 (MIC >100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

57 (MIC 100 uM), E.coli ATCC 25922 (MIC >100 uM), P. faecalis X29 (MIC 6.3 uM), and fungi C.glabrata 090902 (MIC >100 uM), C.albicans(ATCC 10231 (MIC>100 uM).
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 18 Activity

Activity

10% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
10% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 19 Activity

Activity

15% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
15% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014