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Peptide record

TPDB11388

Antibacterial Anticancer Antiviral Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB11388
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ATCYCRTGRCATRESLSGVCRISGRLYRLCCR
Physicochemical Analysis
C145H249N53O43S6
NDQHKMFPW
R
3615.26
9.30
7
1
9
+6
2.95
-0.144
64.06
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3355
92.80
14
Residue Composition
number
2
A
7
R
0
N
0
D
6
C
1
E
0
Q
3
G
0
H
1
I
3
L
0
K
0
M
0
F
0
P
3
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 7 N: 0 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 0 M: 0 F: 0 P: 0 S: 3 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
32
C145H249N53O43S6
3615.26
9.30
+6
2.95
-0.144
Evidence Records 3 records
Evidence 1 Activity

Activity

0.5% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0.5% Hemolysis | 100 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Design of a potent antibiotic peptide based on the active region of human defensin 5. | J Med Chem | 2019
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human cervical epithelial cells CaSki

Target

Human cervical epithelial cells CaSki

Source & Reference

NA
DBAASP
Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | J Virol | 2013
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.23269800]No cytotoxicity against CaSki cells up to 100µg/ ml.

Source & Reference

NA
DRAMP
J Virol. 2013 Mar 87(5):2835-45.