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Peptide record

TPDB11380

Antibacterial Anticancer Antifungal Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11380
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RRIRFRPPRLPRPRPRPWIPPRFPFPRIPGKR
Physicochemical Analysis
C191H307N67O33
ANDCEQHMSTYV
RP
4069.97
13.40
12
0
8
+12
8.13
-1.456
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
135.14
0
Residue Composition
number
0
A
11
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
1
L
1
K
0
M
3
F
11
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 11 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 1 M: 0 F: 3 P: 11 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
32
C191H307N67O33
4069.97
13.40
+12
8.13
-1.456
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli ATCC 25922 (MIC 1 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 7
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

E. faecium ATCC 19434

Source & Reference

dbAMP

Other

active against E. coli ATCC 25922 (MIC 1 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATC
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

active against E. coli ATCC 25922 (MIC 1 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa
Evidence 4 Activity

Activity

MIC
Antibacterial
1 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

TCC 25922 (MIC 1 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans
Evidence 5 Activity

Activity

MIC
Antibacterial
1 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP

Other

19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. ma
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

23 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. maltophilia ATCC 13637 (MIC 1 uM), C. a
Evidence 7 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

E. agglomerans clinical isolate

Source & Reference

dbAMP

Other

0603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. maltophilia ATCC 13637 (MIC 1 uM), C. albicans ATCC 90029 (MIC 0.5 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
1 µM

Target

Stenotrophomonas maltophilia ATCC 13637

Source & Reference

dbAMP

Other

1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. maltophilia ATCC 13637 (MIC 1 uM), C. albicans ATCC 90029 (MIC 0.5 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

Candida albicans ATCC 90029

Source & Reference

dbAMP

Other

uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. maltophilia ATCC 13637 (MIC 1 uM), C. albicans ATCC 90029 (MIC 0.5 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
1 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E. coli ATCC 25922 (MIC 1 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 7
Evidence 11 Activity

Activity

MIC
Antifungal
4 µM

Target

E. faecium ATCC 19434

Source & Reference

dbAMP CAFPdb

Other

active against E. coli ATCC 25922 (MIC 1 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATC
Evidence 12 Activity

Activity

MIC
Antifungal
16 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb

Other

active against E. coli ATCC 25922 (MIC 1 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa
Evidence 13 Activity

Activity

MIC
Antifungal
1 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb

Other

TCC 25922 (MIC 1 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans
Evidence 14 Activity

Activity

MIC
Antifungal
1 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP CAFPdb

Other

19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. ma
Evidence 15 Activity

Activity

MIC
Antifungal
2 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb

Other

23 (MIC 16 uM), K. pneumoniae ATCC 700603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. maltophilia ATCC 13637 (MIC 1 uM), C. a
Evidence 16 Activity

Activity

MIC
Antifungal
0.5 µM

Target

E. agglomerans clinical isolate

Source & Reference

dbAMP CAFPdb

Other

0603 (MIC 1 uM), A. baumannii ATCC 19606 (MIC 1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. maltophilia ATCC 13637 (MIC 1 uM), C. albicans ATCC 90029 (MIC 0.5 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
1 µM

Target

Stenotrophomonas maltophilia ATCC 13637

Source & Reference

dbAMP CAFPdb

Other

1 uM), P. aeruginosa ATCC 27853 (MIC 2 uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. maltophilia ATCC 13637 (MIC 1 uM), C. albicans ATCC 90029 (MIC 0.5 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
0.5 µM

Target

Candida albicans ATCC 90029

Source & Reference

dbAMP CAFPdb

Other

uM), E. agglomerans clinical isolate (MIC 0.5 uM), S. maltophilia ATCC 13637 (MIC 1 uM), C. albicans ATCC 90029 (MIC 0.5 uM).
Evidence 19 Activity

Activity

0% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
0% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 20 Activity

Activity

0% Killing
Toxicity
32 µM
Cytotoxic
0% Killing | 32 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 21 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:0% Hemolysis=32µM | Cytotoxicity: HaCat: 0% Killing=32µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Oct 6 21(19):7367.