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Peptide record

TPDB11372

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

32 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11372

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLGGAKKNFIIAANKTAPQSVKKTFSCKLYNG

FASTA

>TPDB11372|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=32
GLGGAKKNFIIAANKTAPQSVKKTFSCKLYNG

Formula C151H248N42O42S1

Absent Amino Acids RDEHMW

Common Amino Acids K

Mass 3355.95

PI 10.60

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +6

Boman Index 3.02

Hydrophobicity -0.275

Aliphatic Index 70.31

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 44.40

Polar Residues 10

number

Amino Acid Distribution

A: 4 R: 0 N: 3 D: 0 C: 1 E: 0 Q: 1 G: 4 H: 0 I: 2 L: 2 K: 6 M: 0 F: 2 P: 1 S: 2 T: 2 W: 0 Y: 1 V: 1

Length

Formula

C151H248N42O42S1

Mass

3355.95

10.60

Net Charge

Boman Index

3.02

Hydrophobicity

-0.275

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.4 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.7 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.4 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

inst E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.4 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.7 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.4 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

inst E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9.4 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.7 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9.4 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

inst E. coli (MIC 9.4 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 4.7 ug/ml), and C. albicans (MIC 9.4 ug/ml). Aslo histamine release.

Evidence 13 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 14 Activity

Activity

Activity Endpoint (41.8±7.2)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(41.8±7.2)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:17272268]Non-hemolytic activity against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.