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Peptide record

TPDB11371

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB11371
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
Physicochemical Analysis
C156H234N46O46S7
DQKPW
C
3714.27
8.02
5
1
10
+2
0.04
-0.000
36.56
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
4845
130.44
17
Residue Composition
number
1
A
3
R
1
N
0
D
6
C
1
E
0
Q
2
G
2
H
1
I
1
L
0
K
1
M
2
F
0
P
3
S
4
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 2 H: 2 I: 1 L: 1 K: 0 M: 1 F: 2 P: 0 S: 3 T: 4 W: 0 Y: 3 V: 1
Chemical Descriptors
32
C156H234N46O46S7
3714.27
8.02
+2
0.04
-0.000
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
It had been puzzling regarding the role of this defensin. Recent studies revealed two mechanisms: First, HD-6 is a true AMP that kills bacteria under a reduced environmental conditions (2mM DTT in vitro) ( Schroeder BO et al., 2014 ). In other words, disulfide bonds are not required for antimicrobial activity. Activity was observed against anaerobic gut commensals (B. adolescentis Ni3,29c, pH 7.4 only L. acidophilus, B. breve, B. longum, S. salivarius ssp thermophilus), but not against some pathogenic strains (E.coli, B.vulgatus, L.fermentum). An APD recommended reading. Second, HD6 is now shown to control enteric bacterial pathogens in vitro and in vivo by binding to bacterial surface proteins. The peptide appears to be able to form fibrils and nanonets that surround and entangle bacteria. These findings support a key role for HD6 in protecting the small intestine against invasion by diverse enteric pathogens and may explain the conservation of HD6 throughout Hominidae evolution Science 2012 .
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
It had been puzzling regarding the role of this defensin. Recent studies revealed two mechanisms: First, HD-6 is a true AMP that kills bacteria under a reduced environmental conditions (2mM DTT in vitro) ( Schroeder BO et al., 2014 ). In other words, disulfide bonds are not required for antimicrobial activity. Activity was observed against anaerobic gut commensals (B. adolescentis Ni3,29c, pH 7.4 only L. acidophilus, B. breve, B. longum, S. salivarius ssp thermophilus), but not against some pathogenic strains (E.coli, B.vulgatus, L.fermentum). An APD recommended reading. Second, HD6 is now shown to control enteric bacterial pathogens in vitro and in vivo by binding to bacterial surface proteins. The peptide appears to be able to form fibrils and nanonets that surround and entangle bacteria. These findings support a key role for HD6 in protecting the small intestine against invasion by diverse enteric pathogens and may explain the conservation of HD6 throughout Hominidae evolution Science 2012 .
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It had been puzzling regarding the role of this defensin. Recent studies revealed two mechanisms: First, HD-6 is a true AMP that kills bacteria under a reduced environmental conditions (2mM DTT in vitro) ( Schroeder BO et al., 2014 ). In other words, disulfide bonds are not required for antimicrobial activity. Activity was observed against anaerobic gut commensals (B. adolescentis Ni3,29c, pH 7.4 only L. acidophilus, B. breve, B. longum, S. salivarius ssp thermophilus), but not against some pathogenic strains (E.coli, B.vulgatus, L.fermentum). An APD recommended reading. Second, HD6 is now shown to control enteric bacterial pathogens in vitro and in vivo by binding to bacterial surface proteins. The peptide appears to be able to form fibrils and nanonets that surround and entangle bacteria. These findings support a key role for HD6 in protecting the small intestine against invasion by diverse enteric pathogens and may explain the conservation of HD6 throughout Hominidae evolution Science 2012 .
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It had been puzzling regarding the role of this defensin. Recent studies revealed two mechanisms: First, HD-6 is a true AMP that kills bacteria under a reduced environmental conditions (2mM DTT in vitro) ( Schroeder BO et al., 2014 ). In other words, disulfide bonds are not required for antimicrobial activity. Activity was observed against anaerobic gut commensals (B. adolescentis Ni3,29c, pH 7.4 only L. acidophilus, B. breve, B. longum, S. salivarius ssp thermophilus), but not against some pathogenic strains (E.coli, B.vulgatus, L.fermentum). An APD recommended reading. Second, HD6 is now shown to control enteric bacterial pathogens in vitro and in vivo by binding to bacterial surface proteins. The peptide appears to be able to form fibrils and nanonets that surround and entangle bacteria. These findings support a key role for HD6 in protecting the small intestine against invasion by diverse enteric pathogens and may explain the conservation of HD6 throughout Hominidae evolution Science 2012 .