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Peptide record

TPDB11369

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB11369
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept i2APP ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFLDIINKLGKTFAGHMLDKIKCTIGTCPPSP
Physicochemical Analysis
C154H251N39O42S3
REQWYV
GIK
3417.10
9.05
5
2
11
+2
3.68
0.159
88.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.66
7
Residue Composition
number
1
A
0
R
1
N
2
D
2
C
0
E
0
Q
4
G
1
H
4
I
3
L
4
K
1
M
2
F
3
P
1
S
3
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 2 C: 2 E: 0 Q: 0 G: 4 H: 1 I: 4 L: 3 K: 4 M: 1 F: 2 P: 3 S: 1 T: 3 W: 0 Y: 0 V: 0
Chemical Descriptors
32
C154H251N39O42S3
3417.10
9.05
+2
3.68
0.159
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
60 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
weakly active against S. aureus (MIC 60 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
60 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
weakly active against S. aureus (MIC 60 uM).
Evidence 3 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
weakly active against S. aureus (MIC 60 uM).
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
20 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 20 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana | Biochem Biophys Res Commun | 1998
Evidence 5 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.9784389] Have no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 1998 Sep 29 250(3):589-592.