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Peptide record

TPDB11368

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB11368
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILSSFKGVAKGVAKDLAGKLLETLKCKITGC
Physicochemical Analysis
C145H254N38O41S2
RNQHMPWY
K
3249.96
9.98
6
2
13
+4
4.38
0.444
112.81
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.85
6
Residue Composition
number
3
A
0
R
0
N
1
D
2
C
1
E
0
Q
5
G
0
H
2
I
5
L
6
K
0
M
1
F
0
P
2
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 1 C: 2 E: 1 Q: 0 G: 5 H: 0 I: 2 L: 5 K: 6 M: 0 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
32
C145H254N38O41S2
3249.96
9.98
+4
4.38
0.444
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli ATCC 25726

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25726 (MIC 4 uM) and S. aureus ATCC 25923 (MIC 8 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25726 (MIC 4 uM) and S. aureus ATCC 25923 (MIC 8 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli ATCC 25726

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25726 (MIC 4 uM) and S. aureus ATCC 25923 (MIC 8 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli ATCC 25726 (MIC 4 uM) and S. aureus ATCC 25923 (MIC 8 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Escherichia coli ATCC 25726

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25726 (MIC 4 uM) and S. aureus ATCC 25923 (MIC 8 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25726 (MIC 4 uM) and S. aureus ATCC 25923 (MIC 8 uM).
Evidence 7 Activity

Activity

Hemolysis
[Ref.17451843] LD50=150 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides. 2007 Jun 28(6):1268-1274.##Biochim Biophys Acta. 2008 Jun 1784(6):924-929.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
50% Hemolysis | 160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: identification of a full length helix-turn-helix motif. | Biochim Biophys Acta | 2008
Evidence 9 Activity

Activity

LD50
Toxicity
150 µM
Hemolytic
Hemolytic_activity: [Ref.17451843] LD50=150 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2007 Jun 28(6):1268-1274.##Biochim Biophys Acta. 2008 Jun 1784(6):924-929.
Evidence 10 Hemolysis

Activity

[Ref.17451843] LD50=150 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides. 2007 Jun 28(6):1268-1274.##Biochim Biophys Acta. 2008 Jun 1784(6):924-929.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.