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Peptide record

TPDB11367

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB11367
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILSTFKGLAKGVAKDLAGNLLDKFKCKITGC
Physicochemical Analysis
C149H253N39O41S2
REQHMPWY
K
3311.00
9.98
6
2
13
+4
2.68
0.316
103.75
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.78
6
Residue Composition
number
3
A
0
R
1
N
2
D
2
C
0
E
0
Q
5
G
0
H
2
I
5
L
6
K
0
M
2
F
0
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 2 C: 2 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 5 K: 6 M: 0 F: 2 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
32
C149H253N39O41S2
3311.00
9.98
+4
2.68
0.316
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>50 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Tabl
Evidence 2 Activity

Activity

MIC
Antibacterial
7 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith,
Evidence 3 Activity

Activity

MIC
Antibacterial
27 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 4 Activity

Activity

MIC
Antifungal
>50 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Tabl
Evidence 5 Activity

Activity

MIC
Antifungal
7 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith,
Evidence 6 Activity

Activity

MIC
Antifungal
27 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 7 Activity

Activity

MIC
Antiparasitic
>50 µM

Target

C.albicans

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Tabl
Evidence 8 Activity

Activity

MIC
Antiparasitic
7 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith,
Evidence 9 Activity

Activity

MIC
Antiparasitic
27 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against C.albicans (MIC >50 uM), E. coli (MIC 7 uM) and S. aureus (MIC 27 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 10 Activity

Activity

HC50
Hemolysis
120 µM
[Ref.14531844]HC50=120 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Pept Res. 2003 Nov 62(5):207-213.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
120 µM
Hemolytic Cytotoxic
50% Hemolysis | 120 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii. | J Pept Res | 2003
Evidence 12 Activity

Activity

HC50
Toxicity
120 µM
Hemolytic
Hemolytic_activity: [Ref.14531844]HC50=120 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Res. 2003 Nov 62(5):207-213.
Evidence 13 Hemolysis

Activity

120 µM
HC50
[Ref.14531844]HC50=120 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Pept Res. 2003 Nov 62(5):207-213.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.