Back to search

Peptide record

TPDB11366

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11366
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP AI4AVP dbAMP 3.0 DRAVP 2.0 APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ATCYCRTGRCATRESLSGVCEISGRLYRLCCR
Physicochemical Analysis
C144H244N50O45S6
NDQHKMFPW
RC
3588.19
8.59
6
2
9
+4
4.16
-0.113
64.06
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3355
93.50
14
Residue Composition
number
2
A
6
R
0
N
0
D
6
C
2
E
0
Q
3
G
0
H
1
I
3
L
0
K
0
M
0
F
0
P
3
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 6 E: 2 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 0 M: 0 F: 0 P: 0 S: 3 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
32
C144H244N50O45S6
3588.19
8.59
+4
4.16
-0.113
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.7 µg/mL

Target

Escherichia coli ML35 ATCC 43827

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ML35 ATCC 43827 (MIC 4.7 ug/ml) and S. aureus ATCC 25923 (MIC 1.9 ug/ml) (ref, see reduced form SAR). Killed C. difficile
Evidence 2 Activity

Activity

MIC
Antibacterial
1.9 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ML35 ATCC 43827 (MIC 4.7 ug/ml) and S. aureus ATCC 25923 (MIC 1.9 ug/ml) (ref, see reduced form SAR). Killed C. difficile. Human HD5 blocks papillomavirus infecti
Evidence 3 Activity

Activity

MIC
Antifungal
4.7 µg/mL

Target

Escherichia coli ML35 ATCC 43827

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ML35 ATCC 43827 (MIC 4.7 ug/ml) and S. aureus ATCC 25923 (MIC 1.9 ug/ml) (ref, see reduced form SAR). Killed C. difficile
Evidence 4 Activity

Activity

MIC
Antifungal
1.9 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ML35 ATCC 43827 (MIC 4.7 ug/ml) and S. aureus ATCC 25923 (MIC 1.9 ug/ml) (ref, see reduced form SAR). Killed C. difficile. Human HD5 blocks papillomavirus infecti
Evidence 5 Activity

Activity

MIC
Antiparasitic
4.7 µg/mL

Target

Escherichia coli ML35 ATCC 43827

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli ML35 ATCC 43827 (MIC 4.7 ug/ml) and S. aureus ATCC 25923 (MIC 1.9 ug/ml) (ref, see reduced form SAR). Killed C. difficile
Evidence 6 Activity

Activity

MIC
Antiparasitic
1.9 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. coli ML35 ATCC 43827 (MIC 4.7 ug/ml) and S. aureus ATCC 25923 (MIC 1.9 ug/ml) (ref, see reduced form SAR). Killed C. difficile. Human HD5 blocks papillomavirus infecti
Evidence 7 Activity

Activity

MIC
Antiviral
4.7 µg/mL

Target

Escherichia coli ML35 ATCC 43827

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against E. coli ML35 ATCC 43827 (MIC 4.7 ug/ml) and S. aureus ATCC 25923 (MIC 1.9 ug/ml) (ref, see reduced form SAR). Killed C. difficile
Evidence 8 Activity

Activity

MIC
Antiviral
1.9 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against E. coli ML35 ATCC 43827 (MIC 4.7 ug/ml) and S. aureus ATCC 25923 (MIC 1.9 ug/ml) (ref, see reduced form SAR). Killed C. difficile. Human HD5 blocks papillomavirus infecti
Evidence 9 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of human α-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs. | Peptides | 2015
Evidence 10 Activity

Activity

20% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 25 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. | Antimicrob Agents Chemother | 2018
Evidence 11 Activity

Activity

33% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
33% Hemolysis | 50 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. | Antimicrob Agents Chemother | 2018
Evidence 12 Activity

Activity

40% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
40% Hemolysis | 100 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. | Antimicrob Agents Chemother | 2018
Evidence 13 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. | Antimicrob Agents Chemother | 2018
Evidence 14 Activity

Activity

50% Cytotoxicity
Toxicity
24 µM
Cytotoxic
50% Cytotoxicity | 24 | µM | target cell: Human retinal epithelial cells ARPE-19

Target

Human retinal epithelial cells ARPE-19

Source & Reference

NA
DBAASP
The Human ?-Defensin-Derived Peptide HD5(1-9) Inhibits Cellular Attachment and Entry of Human Cytomegalovirus | Antiviral Res | 2020
Evidence 15 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human cervical epithelial cells CaSki

Target

Human cervical epithelial cells CaSki

Source & Reference

NA
DBAASP
Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | J Virol | 2013
Evidence 16 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26206286] It has 0% hemolysis at 100µM against human red blood cells. | Cytotoxicity: [Ref.34206990]No cytotoxicity on HEK293T cells up to 50 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
Viruses. 2021 Jun 26 13(7):1246.##Nat Immunol. 2002 Jun 3(6):583-590.##Antimicrob Agents Chemother. 2005 Jan 49(1):269-275.##Peptides. 2015 Sep 71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.
Evidence 17 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.