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Peptide record

TPDB11360

Antibacterial Antifungal Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11360
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VKVGINGFGRIGRLVTRAAFHGKKVEVVAIND
Physicochemical Analysis
C154H258N48O40
CQMPSWY
V
3422.04
11.46
7
2
15
+4
6.80
0.263
112.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
3
A
3
R
2
N
1
D
0
C
1
E
0
Q
5
G
1
H
3
I
1
L
3
K
0
M
2
F
0
P
0
S
1
T
0
W
0
Y
6
V
Amino Acid Distribution
A: 3 R: 3 N: 2 D: 1 C: 0 E: 1 Q: 0 G: 5 H: 1 I: 3 L: 1 K: 3 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 6
Chemical Descriptors
32
C154H258N48O40
3422.04
11.46
+4
6.80
0.263
Evidence Records 26 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.2-11 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Showed bacteriostatic activity. Active against B. subtilis (MIC 3.2-11 ug/ml), M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram-
Evidence 2 Activity

Activity

MIC
Antibacterial
9.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Showed bacteriostatic activity. Active against B. subtilis (MIC 3.2-11 ug/ml), M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml
Evidence 3 Activity

Activity

MIC
Antibacterial
11.3 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

tatic activity. Active against B. subtilis (MIC 3.2-11 ug/ml), M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or K
Evidence 4 Activity

Activity

MIC
Antibacterial
13.5 µg/mL

Target

S. iniae

Source & Reference

dbAMP DRAMP

Other

st B. subtilis (MIC 3.2-11 ug/ml), M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml)
Evidence 5 Activity

Activity

MIC
Antibacterial
14 µg/mL

Target

A. hydrophila

Source & Reference

dbAMP DRAMP

Other

, M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug
Evidence 6 Activity

Activity

MIC
Antibacterial
3.2-6.9 µg/mL

Target

Escherichia coli D31 or ML35p or KCTC1116

Source & Reference

dbAMP DRAMP

Other

. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexner
Evidence 7 Activity

Activity

MIC
Antibacterial
4.3 µg/mL

Target

Pseudomonas aeruginosa KCTC2004

Source & Reference

dbAMP DRAMP

Other

Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KC
Evidence 8 Activity

Activity

MIC
Antibacterial
3.6 µg/mL

Target

S. enterica KCTC2514

Source & Reference

dbAMP DRAMP

Other

oli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KCTC2009 (MIC 9.3 ug/ml), V. parahaemoly
Evidence 9 Activity

Activity

MIC
Antibacterial
4.8 µg/mL

Target

S. flexneri KCTC2517

Source & Reference

dbAMP DRAMP

Other

6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KCTC2009 (MIC 9.3 ug/ml), V. parahaemolyticus (MIC 6.2 ug/mL), and C.albicans
Evidence 10 Activity

Activity

MIC
Antibacterial
9.3 µg/mL

Target

S. sonnei KCTC2009

Source & Reference

dbAMP DRAMP

Other

C 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KCTC2009 (MIC 9.3 ug/ml), V. parahaemolyticus (MIC 6.2 ug/mL), and C.albicans (>125 ug/ml). Its activity was bacte
Evidence 11 Activity

Activity

MIC
Antibacterial
6.2 ug/mL

Target

V. parahaemolyticus

Source & Reference

dbAMP DRAMP

Other

MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KCTC2009 (MIC 9.3 ug/ml), V. parahaemolyticus (MIC 6.2 ug/mL), and C.albicans (>125 ug/ml). Its activity was bacteriostatic.
Evidence 12 Activity

Activity

MIC
Antifungal
3.2-11 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Showed bacteriostatic activity. Active against B. subtilis (MIC 3.2-11 ug/ml), M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram-
Evidence 13 Activity

Activity

MIC
Antifungal
9.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Showed bacteriostatic activity. Active against B. subtilis (MIC 3.2-11 ug/ml), M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml
Evidence 14 Activity

Activity

MIC
Antifungal
11.3 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

tatic activity. Active against B. subtilis (MIC 3.2-11 ug/ml), M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or K
Evidence 15 Activity

Activity

MIC
Antifungal
13.5 µg/mL

Target

S. iniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

st B. subtilis (MIC 3.2-11 ug/ml), M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml)
Evidence 16 Activity

Activity

MIC
Antifungal
14 µg/mL

Target

A. hydrophila

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, M. luteus (MIC 9.5 ug/ml), S. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug
Evidence 17 Activity

Activity

MIC
Antifungal
3.2-6.9 µg/mL

Target

Escherichia coli D31 or ML35p or KCTC1116

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. aureus (MIC 11.3 ug/ml), S. iniae (MIC 13.5 ug/ml), Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexner
Evidence 18 Activity

Activity

MIC
Antifungal
4.3 µg/mL

Target

Pseudomonas aeruginosa KCTC2004

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram- A. hydrophila (MIC 14 ug/ml), E. coli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KC
Evidence 19 Activity

Activity

MIC
Antifungal
3.6 µg/mL

Target

S. enterica KCTC2514

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

oli D31 or ML35p or KCTC1116 (MIC 3.2-6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KCTC2009 (MIC 9.3 ug/ml), V. parahaemoly
Evidence 20 Activity

Activity

MIC
Antifungal
4.8 µg/mL

Target

S. flexneri KCTC2517

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

6.9 ug/ml), P. aeruginosa KCTC2004 (MIC 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KCTC2009 (MIC 9.3 ug/ml), V. parahaemolyticus (MIC 6.2 ug/mL), and C.albicans
Evidence 21 Activity

Activity

MIC
Antifungal
9.3 µg/mL

Target

S. sonnei KCTC2009

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 4.3 ug/ml), S. enterica KCTC2514 (MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KCTC2009 (MIC 9.3 ug/ml), V. parahaemolyticus (MIC 6.2 ug/mL), and C.albicans (>125 ug/ml). Its activity was bacte
Evidence 22 Activity

Activity

MIC
Antifungal
6.2 ug/mL

Target

V. parahaemolyticus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 3.6 ug/ml), S. flexneri KCTC2517 (MIC 4.8 ug/ml), S. sonnei KCTC2009 (MIC 9.3 ug/ml), V. parahaemolyticus (MIC 6.2 ug/mL), and C.albicans (>125 ug/ml). Its activity was bacteriostatic.
Evidence 23 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares. | Fish Shellfish Immunol | 2012
Evidence 24 Activity

Activity

3% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares. | Fish Shellfish Immunol | 2012
Evidence 25 Activity

Activity

% Hemolysis
Toxicity
0.4 %
Hemolytic
Hemolytic_activity: [Ref.22771964]0.4% hemolysis at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Fish Shellfish Immunol. 2012 Oct 33(4):743-52. doi: 10.1016/j.fsi.2012.06.023.
Evidence 26 Activity

Activity

% Hemolysis
Toxicity
2.7 %
Hemolytic
Hemolytic_activity: [Ref.22771964]2.7% hemolysis at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Fish Shellfish Immunol. 2012 Oct 33(4):743-52. doi: 10.1016/j.fsi.2012.06.023.