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Peptide record

TPDB11349

Antibacterial Antifungal Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB11349
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
WGHKLRSSWNKVKHAVKKGAGYASGACRVLGH
Physicochemical Analysis
C156H246N52O38S1
DEQIMFPT
GK
3490.05
11.11
10
0
12
+7
3.84
-0.600
64.06
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
12490
357.87
6
Residue Composition
number
4
A
2
R
1
N
0
D
1
C
0
E
0
Q
5
G
3
H
0
I
2
L
5
K
0
M
0
F
0
P
3
S
0
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 5 H: 3 I: 0 L: 2 K: 5 M: 0 F: 0 P: 0 S: 3 T: 0 W: 2 Y: 1 V: 3
Chemical Descriptors
32
C156H246N52O38S1
3490.05
11.11
+7
3.84
-0.600
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ B. subtilis (MIC 6.25 uM), C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram
Evidence 2 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

C. glutamicum

Source & Reference

dbAMP

Other

Active against Gram+ B. subtilis (MIC 6.25 uM), C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against Gram+ B. subtilis (MIC 6.25 uM), C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-
Evidence 4 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

st Gram+ B. subtilis (MIC 6.25 uM), C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (
Evidence 5 Activity

Activity

MIC
Antibacterial
1.56-6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (MIC 25 uM), C. albicans (MIC 50 uM
Evidence 6 Activity

Activity

MIC
Antibacterial
0.78-6.25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (MIC 25 uM), C. albicans (MIC 50 uM), Cladosporium sp. (MIC 12.5 uM),
Evidence 7 Activity

Activity

MIC
Antibacterial
25 µM

Target

A. pullulans

Source & Reference

dbAMP

Other

(MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (MIC 25 uM), C. albicans (MIC 50 uM), Cladosporium sp. (MIC 12.5 uM), Rhodotorula sp. (MIC 3.13 uM),
Evidence 8 Activity

Activity

MIC
Antibacterial
50 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

oli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (MIC 25 uM), C. albicans (MIC 50 uM), Cladosporium sp. (MIC 12.5 uM), Rhodotorula sp. (MIC 3.13 uM), and S. cerevisiae (MIC 12
Evidence 9 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

albicans (MIC 50 uM), Cladosporium sp. (MIC 12.5 uM), Rhodotorula sp. (MIC 3.13 uM), and S. cerevisiae (MIC 12.5 uM). Updated 7/2021 5/2024
Evidence 10 Activity

Activity

MIC
Antifungal
6.25 µM

Target

B. subtilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ B. subtilis (MIC 6.25 uM), C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram
Evidence 11 Activity

Activity

MIC
Antifungal
0.78 µM

Target

C. glutamicum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ B. subtilis (MIC 6.25 uM), C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM),
Evidence 12 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ B. subtilis (MIC 6.25 uM), C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-
Evidence 13 Activity

Activity

MIC
Antifungal
3.13 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

st Gram+ B. subtilis (MIC 6.25 uM), C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (
Evidence 14 Activity

Activity

MIC
Antifungal
1.56-6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

C. glutamicum (MIC 0.78 uM), S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (MIC 25 uM), C. albicans (MIC 50 uM
Evidence 15 Activity

Activity

MIC
Antifungal
0.78-6.25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S. aureus (MIC 6.25 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (MIC 25 uM), C. albicans (MIC 50 uM), Cladosporium sp. (MIC 12.5 uM),
Evidence 16 Activity

Activity

MIC
Antifungal
25 µM

Target

A. pullulans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 3.13 uM), Gram- E. coli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (MIC 25 uM), C. albicans (MIC 50 uM), Cladosporium sp. (MIC 12.5 uM), Rhodotorula sp. (MIC 3.13 uM),
Evidence 17 Activity

Activity

MIC
Antifungal
50 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

oli (MIC 1.56-6.25 uM), P. aeruginosa (MIC 0.78-6.25 uM), fungi A. pullulans (MIC 25 uM), C. albicans (MIC 50 uM), Cladosporium sp. (MIC 12.5 uM), Rhodotorula sp. (MIC 3.13 uM), and S. cerevisiae (MIC 12
Evidence 18 Activity

Activity

MIC
Antifungal
12.5 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

albicans (MIC 50 uM), Cladosporium sp. (MIC 12.5 uM), Rhodotorula sp. (MIC 3.13 uM), and S. cerevisiae (MIC 12.5 uM). Updated 7/2021 5/2024
Evidence 19 Activity

Activity

12% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
12% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications. | PLoS One | 2016
Evidence 20 Activity

Activity

19% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
19% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications. | PLoS One | 2016
Evidence 21 Activity

Activity

56% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
56% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications. | PLoS One | 2016
Evidence 22 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.