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Peptide record

TPDB11348

Anti-inflammatory Antibacterial Antifungal Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB11348
Anti-inflammatory Antibacterial Antifungal Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
ASENGKCNLLCLVKKKLRAVGNVIKTVVGKIA
Physicochemical Analysis
C148H268N44O40S2
DQHMFPWY
K
3368.15
10.54
7
1
14
+6
6.83
0.344
127.81
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
3.71
7
Residue Composition
number
3
A
1
R
3
N
0
D
2
C
1
E
0
Q
3
G
0
H
2
I
4
L
6
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 3 R: 1 N: 3 D: 0 C: 2 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 4 K: 6 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 5
Chemical Descriptors
32
C148H268N44O40S2
3368.15
10.54
+6
6.83
0.344
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.69 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- bacteria E. coli ATCC 25922 (MIC 0.69 uM), S. paratyphi A ATCC 9150 (MIC 1.39 uM), P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii
Evidence 2 Activity

Activity

MIC
Antibacterial
1.39 µM

Target

S. paratyphi A ATCC 9150

Source & Reference

dbAMP

Other

Active against Gram- bacteria E. coli ATCC 25922 (MIC 0.69 uM), S. paratyphi A ATCC 9150 (MIC 1.39 uM), P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteri
Evidence 3 Activity

Activity

MIC
Antibacterial
1.39 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

Gram- bacteria E. coli ATCC 25922 (MIC 0.69 uM), S. paratyphi A ATCC 9150 (MIC 1.39 uM), P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteria S. epidermidis ATCC 12228 (MIC 5.57 uM
Evidence 4 Activity

Activity

MIC
Antibacterial
2.78 µM

Target

A. junii ATCC 17908

Source & Reference

dbAMP

Other

0.69 uM), S. paratyphi A ATCC 9150 (MIC 1.39 uM), P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteria S. epidermidis ATCC 12228 (MIC 5.57 uM), S. haemolyticus ATCC 29970 (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
5.57 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP

Other

P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteria S. epidermidis ATCC 12228 (MIC 5.57 uM), S. haemolyticus ATCC 29970 (MIC 5.57 uM), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C.
Evidence 6 Activity

Activity

MIC
Antibacterial
5.57 µM

Target

Staphylococcus haemolyticus ATCC 29970

Source & Reference

dbAMP

Other

. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteria S. epidermidis ATCC 12228 (MIC 5.57 uM), S. haemolyticus ATCC 29970 (MIC 5.57 uM), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C. glabrata ATCC 66032 (MIC 1.39 uM), and C.
Evidence 7 Activity

Activity

MIC
Antibacterial
5.57 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP

Other

cteria S. epidermidis ATCC 12228 (MIC 5.57 uM), S. haemolyticus ATCC 29970 (MIC 5.57 uM), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C. glabrata ATCC 66032 (MIC 1.39 uM), and C. albicans ATCC 14053 (MIC 5.57 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
1.39 µM

Target

C. glabrata ATCC 66032

Source & Reference

dbAMP

Other

M), S. haemolyticus ATCC 29970 (MIC 5.57 uM), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C. glabrata ATCC 66032 (MIC 1.39 uM), and C. albicans ATCC 14053 (MIC 5.57 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
5.57 µM

Target

Candida albicans ATCC 14053

Source & Reference

dbAMP

Other

M), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C. glabrata ATCC 66032 (MIC 1.39 uM), and C. albicans ATCC 14053 (MIC 5.57 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
0.69 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- bacteria E. coli ATCC 25922 (MIC 0.69 uM), S. paratyphi A ATCC 9150 (MIC 1.39 uM), P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii
Evidence 11 Activity

Activity

MIC
Antifungal
1.39 µM

Target

S. paratyphi A ATCC 9150

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- bacteria E. coli ATCC 25922 (MIC 0.69 uM), S. paratyphi A ATCC 9150 (MIC 1.39 uM), P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteri
Evidence 12 Activity

Activity

MIC
Antifungal
1.39 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Gram- bacteria E. coli ATCC 25922 (MIC 0.69 uM), S. paratyphi A ATCC 9150 (MIC 1.39 uM), P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteria S. epidermidis ATCC 12228 (MIC 5.57 uM
Evidence 13 Activity

Activity

MIC
Antifungal
2.78 µM

Target

A. junii ATCC 17908

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0.69 uM), S. paratyphi A ATCC 9150 (MIC 1.39 uM), P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteria S. epidermidis ATCC 12228 (MIC 5.57 uM), S. haemolyticus ATCC 29970 (MIC
Evidence 14 Activity

Activity

MIC
Antifungal
5.57 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP CAFPdb Antifungipept

Other

P. aeruginosa ATCC 27853 (MIC 1.39 uM), A. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteria S. epidermidis ATCC 12228 (MIC 5.57 uM), S. haemolyticus ATCC 29970 (MIC 5.57 uM), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C.
Evidence 15 Activity

Activity

MIC
Antifungal
5.57 µM

Target

Staphylococcus haemolyticus ATCC 29970

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. junii ATCC 17908 (MIC 2.78 uM), Gram+ bacteria S. epidermidis ATCC 12228 (MIC 5.57 uM), S. haemolyticus ATCC 29970 (MIC 5.57 uM), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C. glabrata ATCC 66032 (MIC 1.39 uM), and C.
Evidence 16 Activity

Activity

MIC
Antifungal
5.57 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP CAFPdb Antifungipept

Other

cteria S. epidermidis ATCC 12228 (MIC 5.57 uM), S. haemolyticus ATCC 29970 (MIC 5.57 uM), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C. glabrata ATCC 66032 (MIC 1.39 uM), and C. albicans ATCC 14053 (MIC 5.57 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
1.39 µM

Target

C. glabrata ATCC 66032

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), S. haemolyticus ATCC 29970 (MIC 5.57 uM), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C. glabrata ATCC 66032 (MIC 1.39 uM), and C. albicans ATCC 14053 (MIC 5.57 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
5.57 µM

Target

Candida albicans ATCC 14053

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), E. faecalis ATCC 29212 (MIC 5.57 uM), fungi C. glabrata ATCC 66032 (MIC 1.39 uM), and C. albicans ATCC 14053 (MIC 5.57 uM).
Evidence 19 Activity

Activity

5.65% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
5.65% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
The first identified cathelicidin from tree frogs possesses anti-inflammatory and partial LPS neutralization activities. | Amino Acids | 2017
Evidence 20 Activity

Activity

7.06% cell death
Toxicity
200 µg/mL
Cytotoxic
7.06% cell death | 200 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
The first identified cathelicidin from tree frogs possesses anti-inflammatory and partial LPS neutralization activities. | Amino Acids | 2017