TPDB11340

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.34 µg/mL

Target

Target Organism D. bacillus IS

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against Gram- E. coli ATCC25922, IS series (MIC 9.38 ug/ml), D. bacillus IS (MIC 2.34 ug/ml), K. pneumoniae IS sereis (MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirab

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism Klebsiella pneumoniae IS sereis

Source & Reference

Database Source dbAMP

Other

Evidence Text

nst Gram- E. coli ATCC25922, IS series (MIC 9.38 ug/ml), D. bacillus IS (MIC 2.34 ug/ml), K. pneumoniae IS sereis (MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.69 µg/mL

Target

Target Organism Klebsiella oxytoca IS

Source & Reference

Database Source dbAMP

Other

Evidence Text

ug/ml), D. bacillus IS (MIC 2.34 ug/ml), K. pneumoniae IS sereis (MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism P. mirabilis IS

Source & Reference

Database Source dbAMP

Other

Evidence Text

4 ug/ml), K. pneumoniae IS sereis (MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia IS 090223 (MIC 9.38 ug/ml), P. aer

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism Stenotrophomonas maltophilia IS 7404

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia IS 090223 (MIC 9.38 ug/ml), P. aeruginosa ATCC 27853 IS sereis (MIC 9.38-

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism Stenotrophomonas maltophilia IS 090223

Source & Reference

Database Source dbAMP

Other

Evidence Text

MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia IS 090223 (MIC 9.38 ug/ml), P. aeruginosa ATCC 27853 IS sereis (MIC 9.38-18.75 ug/ml), S. paratyphi IS IC 9.38 uM),

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 IS sereis

Source & Reference

Database Source dbAMP

Other

Evidence Text

ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia IS 090223 (MIC 9.38 ug/ml), P. aeruginosa ATCC 27853 IS sereis (MIC 9.38-18.75 ug/ml), S. paratyphi IS IC 9.38 uM), Gram+ S.aureus ATCC25922 (MIC >200 ug/ml), S. aureus IS 130

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >200 µg/mL

Target

Target Organism S.aureus ATCC25922

Source & Reference

Database Source dbAMP

Other

Evidence Text

eruginosa ATCC 27853 IS sereis (MIC 9.38-18.75 ug/ml), S. paratyphi IS IC 9.38 uM), Gram+ S.aureus ATCC25922 (MIC >200 ug/ml), S. aureus IS 1307 or 08032XXX (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.69-8.75 µg/mL

Target

Target Organism Staphylococcus aureus IS 1307 or 08032XXX

Source & Reference

Database Source dbAMP

Other

Evidence Text

.38-18.75 ug/ml), S. paratyphi IS IC 9.38 uM), Gram+ S.aureus ATCC25922 (MIC >200 ug/ml), S. aureus IS 1307 or 08032XXX (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.34 µg/mL

Target

Target Organism B. cereus IS

Source & Reference

Database Source dbAMP

Other

Evidence Text

.aureus ATCC25922 (MIC >200 ug/ml), S. aureus IS 1307 or 08032XXX (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (M

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism B. subtilis IS

Source & Reference

Database Source dbAMP

Other

Evidence Text

ml), S. aureus IS 1307 or 08032XXX (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism E. faecium IS 1299

Source & Reference

Database Source dbAMP

Other

Evidence Text

X (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism N. asteroids IS

Source & Reference

Database Source dbAMP

Other

Evidence Text

S (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >200 µg/mL

Target

Target Organism Enterococcus faecalis IS981

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS 08022821 (MIC >200 ug/ml), C. albi

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

99 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS 08022821 (MIC >200 ug/ml), C. albicans other IS strains (MIC 9.38-18

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans IS 08022821

Source & Reference

Database Source dbAMP

Other

Evidence Text

C 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS 08022821 (MIC >200 ug/ml), C. albicans other IS strains (MIC 9.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. gla

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism Candida albicans other IS strains

Source & Reference

Database Source dbAMP

Other

Evidence Text

ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS 08022821 (MIC >200 ug/ml), C. albicans other IS strains (MIC 9.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. glabrata IS 08A802 (MIC 8.38-75 ug/ml), C.neoformans IS

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism A. cinerea

Source & Reference

Database Source dbAMP

Other

Evidence Text

bicans IS 08022821 (MIC >200 ug/ml), C. albicans other IS strains (MIC 9.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. glabrata IS 08A802 (MIC 8.38-75 ug/ml), C.neoformans IS (MIC >200 ug/ml), aquatic pat

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.38-75 µg/mL

Target

Target Organism C. glabrata IS 08A802

Source & Reference

Database Source dbAMP

Other

Evidence Text

ug/ml), C. albicans other IS strains (MIC 9.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. glabrata IS 08A802 (MIC 8.38-75 ug/ml), C.neoformans IS (MIC >200 ug/ml), aquatic pathogenic bacteria V. harveyi (MIC 18.75 ug/m

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >200 µg/mL

Target

Target Organism C.neoformans IS

Source & Reference

Database Source dbAMP

Other

Evidence Text

.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. glabrata IS 08A802 (MIC 8.38-75 ug/ml), C.neoformans IS (MIC >200 ug/ml), aquatic pathogenic bacteria V. harveyi (MIC 18.75 ug/ml), V. parahaemolyticus (MIC 18.75

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism V. harveyi

Source & Reference

Database Source dbAMP

Other

Evidence Text

08A802 (MIC 8.38-75 ug/ml), C.neoformans IS (MIC >200 ug/ml), aquatic pathogenic bacteria V. harveyi (MIC 18.75 ug/ml), V. parahaemolyticus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (M

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP

Other

Evidence Text

neoformans IS (MIC >200 ug/ml), aquatic pathogenic bacteria V. harveyi (MIC 18.75 ug/ml), V. parahaemolyticus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism V. brasiliensis

Source & Reference

Database Source dbAMP

Other

Evidence Text

pathogenic bacteria V. harveyi (MIC 18.75 ug/ml), V. parahaemolyticus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A.

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism V. cholerae

Source & Reference

Database Source dbAMP

Other

Evidence Text

C 18.75 ug/ml), V. parahaemolyticus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), a

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 37.5 µg/mL

Target

Target Organism E. tarda

Source & Reference

Database Source dbAMP

Other

Evidence Text

icus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), and A. veronii (MIC 18.75 ug

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism A. sobria

Source & Reference

Database Source dbAMP

Other

Evidence Text

brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), and A. veronii (MIC 18.75 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism A. hydrophila

Source & Reference

Database Source dbAMP

Other

Evidence Text

l), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), and A. veronii (MIC 18.75 ug/ml).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism A. veronii

Source & Reference

Database Source dbAMP

Other

Evidence Text

. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), and A. veronii (MIC 18.75 ug/ml).

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.34 µg/mL

Target

Target Organism D. bacillus IS

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against Gram- E. coli ATCC25922, IS series (MIC 9.38 ug/ml), D. bacillus IS (MIC 2.34 ug/ml), K. pneumoniae IS sereis (MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirab

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism Klebsiella pneumoniae IS sereis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

nst Gram- E. coli ATCC25922, IS series (MIC 9.38 ug/ml), D. bacillus IS (MIC 2.34 ug/ml), K. pneumoniae IS sereis (MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.69 µg/mL

Target

Target Organism Klebsiella oxytoca IS

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ug/ml), D. bacillus IS (MIC 2.34 ug/ml), K. pneumoniae IS sereis (MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism P. mirabilis IS

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

4 ug/ml), K. pneumoniae IS sereis (MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia IS 090223 (MIC 9.38 ug/ml), P. aer

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µg/mL

Target

Target Organism Stenotrophomonas maltophilia IS 7404

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 9.38-18.75 ug/ml), K. oxytoca IS (MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia IS 090223 (MIC 9.38 ug/ml), P. aeruginosa ATCC 27853 IS sereis (MIC 9.38-

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism Stenotrophomonas maltophilia IS 090223

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

MIC 4.69 ug/ml), P. mirabilis IS (MIC 9.38 ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia IS 090223 (MIC 9.38 ug/ml), P. aeruginosa ATCC 27853 IS sereis (MIC 9.38-18.75 ug/ml), S. paratyphi IS IC 9.38 uM),

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 IS sereis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ug/ml), S. maltophilia IS 7404 (MIC 75 ug/ml), S. maltophilia IS 090223 (MIC 9.38 ug/ml), P. aeruginosa ATCC 27853 IS sereis (MIC 9.38-18.75 ug/ml), S. paratyphi IS IC 9.38 uM), Gram+ S.aureus ATCC25922 (MIC >200 ug/ml), S. aureus IS 130

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >200 µg/mL

Target

Target Organism S.aureus ATCC25922

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

eruginosa ATCC 27853 IS sereis (MIC 9.38-18.75 ug/ml), S. paratyphi IS IC 9.38 uM), Gram+ S.aureus ATCC25922 (MIC >200 ug/ml), S. aureus IS 1307 or 08032XXX (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B.

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.69-8.75 µg/mL

Target

Target Organism Staphylococcus aureus IS 1307 or 08032XXX

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

.38-18.75 ug/ml), S. paratyphi IS IC 9.38 uM), Gram+ S.aureus ATCC25922 (MIC >200 ug/ml), S. aureus IS 1307 or 08032XXX (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.34 µg/mL

Target

Target Organism B. cereus IS

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

.aureus ATCC25922 (MIC >200 ug/ml), S. aureus IS 1307 or 08032XXX (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (M

Evidence 39 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism B. subtilis IS

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ml), S. aureus IS 1307 or 08032XXX (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981

Evidence 40 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism E. faecium IS 1299

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

X (MIC 4.69- 8.75 ug/ml), B. cereus IS (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC

Evidence 41 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism N. asteroids IS

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

S (MIC 2.34 ug/ml), B. subtilis IS (MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS

Evidence 42 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >200 µg/mL

Target

Target Organism Enterococcus faecalis IS981

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 9.38 ug/ml), E. faecium IS 1299 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS 08022821 (MIC >200 ug/ml), C. albi

Evidence 43 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

99 (MIC 9.38 ug/ml), N. asteroids IS (MIC 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS 08022821 (MIC >200 ug/ml), C. albicans other IS strains (MIC 9.38-18

Evidence 44 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >200 µg/mL

Target

Target Organism C.albicans IS 08022821

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

C 9.38 ug/ml), E.faecalis IS981 (MIC >200 ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS 08022821 (MIC >200 ug/ml), C. albicans other IS strains (MIC 9.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. gla

Evidence 45 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism Candida albicans other IS strains

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ug/ml), S. epidermidis (MIC 18.75 ug/ml), fungi C.albicans IS 08022821 (MIC >200 ug/ml), C. albicans other IS strains (MIC 9.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. glabrata IS 08A802 (MIC 8.38-75 ug/ml), C.neoformans IS

Evidence 46 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism A. cinerea

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

bicans IS 08022821 (MIC >200 ug/ml), C. albicans other IS strains (MIC 9.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. glabrata IS 08A802 (MIC 8.38-75 ug/ml), C.neoformans IS (MIC >200 ug/ml), aquatic pat

Evidence 47 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.38-75 µg/mL

Target

Target Organism C. glabrata IS 08A802

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ug/ml), C. albicans other IS strains (MIC 9.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. glabrata IS 08A802 (MIC 8.38-75 ug/ml), C.neoformans IS (MIC >200 ug/ml), aquatic pathogenic bacteria V. harveyi (MIC 18.75 ug/m

Evidence 48 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >200 µg/mL

Target

Target Organism C.neoformans IS

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

.38-18.75 ug/ml), A. cinerea (MIC 9.38 ug/ml), C. glabrata IS 08A802 (MIC 8.38-75 ug/ml), C.neoformans IS (MIC >200 ug/ml), aquatic pathogenic bacteria V. harveyi (MIC 18.75 ug/ml), V. parahaemolyticus (MIC 18.75

Evidence 49 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism V. harveyi

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

08A802 (MIC 8.38-75 ug/ml), C.neoformans IS (MIC >200 ug/ml), aquatic pathogenic bacteria V. harveyi (MIC 18.75 ug/ml), V. parahaemolyticus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (M

Evidence 50 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

neoformans IS (MIC >200 ug/ml), aquatic pathogenic bacteria V. harveyi (MIC 18.75 ug/ml), V. parahaemolyticus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/

Evidence 51 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism V. brasiliensis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

pathogenic bacteria V. harveyi (MIC 18.75 ug/ml), V. parahaemolyticus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A.

Evidence 52 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism V. cholerae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

C 18.75 ug/ml), V. parahaemolyticus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), a

Evidence 53 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 37.5 µg/mL

Target

Target Organism E. tarda

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

icus (MIC 18.75 ug/ml), V. brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), and A. veronii (MIC 18.75 ug

Evidence 54 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism A. sobria

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

brasiliensis (MIC 18.75 ug/ml), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), and A. veronii (MIC 18.75 ug/ml).

Evidence 55 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism A. hydrophila

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

l), V. cholerae (MIC 18.75 ug/ml), E. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), and A. veronii (MIC 18.75 ug/ml).

Evidence 56 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism A. veronii

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

. tarda (MIC 37.5 ug/ml), A. sobria (MIC 9.38 ug/ml), A. hydrophila (MIC 9.38 ug/ml), and A. veronii (MIC 18.75 ug/ml).

Evidence 57 Activity

Activity

Activity Endpoint 4.35% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

4.35% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Roles of polymorphic cathelicidins in innate immunity of soft-shell turtle, Pelodiscus sinensis. | Dev Comp Immunol | 2019

Evidence 58 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Dev Comp Immunol. 2019 Mar 92:179-192.