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Peptide record

TPDB11327

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11327
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILSSFKGVAKGVAKNLAGKLLDELKCKITGC
Physicochemical Analysis
C145H253N39O41S2
RQHMPWY
K
3262.96
9.98
6
2
13
+4
4.66
0.356
112.81
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.83
6
Residue Composition
number
3
A
0
R
1
N
1
D
2
C
1
E
0
Q
5
G
0
H
2
I
5
L
6
K
0
M
1
F
0
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 2 E: 1 Q: 0 G: 5 H: 0 I: 2 L: 5 K: 6 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
32
C145H253N39O41S2
3262.96
9.98
+4
4.66
0.356
Evidence Records 28 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (M
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococ
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-
Evidence 5 Activity

Activity

MIC
Antibacterial
20 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

i (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-mirabilis (MIC >40 uM),
Evidence 6 Activity

Activity

MIC
Antibacterial
20 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

nosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-mirabilis (MIC >40 uM), E-faecalis (MIC >40 uM), an
Evidence 7 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (M
Evidence 8 Activity

Activity

MIC
Antifungal
5 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis
Evidence 9 Activity

Activity

MIC
Antifungal
5 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococ
Evidence 10 Activity

Activity

MIC
Antifungal
10 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-
Evidence 11 Activity

Activity

MIC
Antifungal
20 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

i (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-mirabilis (MIC >40 uM),
Evidence 12 Activity

Activity

MIC
Antifungal
20 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-mirabilis (MIC >40 uM), E-faecalis (MIC >40 uM), an
Evidence 13 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (M
Evidence 14 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis
Evidence 15 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococ
Evidence 16 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-
Evidence 17 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

i (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-mirabilis (MIC >40 uM),
Evidence 18 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

nosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-mirabilis (MIC >40 uM), E-faecalis (MIC >40 uM), an
Evidence 19 Activity

Activity

MIC
Antiviral
5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (M
Evidence 20 Activity

Activity

MIC
Antiviral
5 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis
Evidence 21 Activity

Activity

MIC
Antiviral
5 µM

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococ
Evidence 22 Activity

Activity

MIC
Antiviral
10 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

Active against E. coli (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-
Evidence 23 Activity

Activity

MIC
Antiviral
20 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

i (MIC 5 uM), P. aeruginosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-mirabilis (MIC >40 uM),
Evidence 24 Activity

Activity

MIC
Antiviral
20 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

nosa (MIC 5 uM), E. cloacae (MIC 5 uM), K. pneumoniae (MIC 10 uM), S. aureus (MIC 20 uM), S. epidermidis (MIC 20 uM), Streptococcus Group B (MIC 20 uM), P-mirabilis (MIC >40 uM), E-faecalis (MIC >40 uM), an
Evidence 25 Activity

Activity

HC50
Hemolysis
290 µM
[Ref.15325526]HC50=290 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Dev Comp Immunol. 2005 29(1):83-90.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
290 µM
Hemolytic Cytotoxic
50% Hemolysis | 290 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora. | Dev Comp Immunol | 2005
Evidence 27 Activity

Activity

HC50
Toxicity
290 µM
Hemolytic
Hemolytic_activity: [Ref.15325526]HC50=290 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Dev Comp Immunol. 2005 29(1):83-90.
Evidence 28 Hemolysis

Activity

290 µM
HC50
[Ref.15325526]HC50=290 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Dev Comp Immunol. 2005 29(1):83-90.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.