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Peptide record

TPDB11323

Antibacterial Anticancer Antifungal Antiparasitic standard

31 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11323

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

SCASRCKSRCRARRCRYYVSVRYGGFCYCRC

FASTA

>TPDB11323|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=31
SCASRCKSRCRARRCRYYVSVRYGGFCYCRC

Formula C152H244N56O40S7

Absent Amino Acids NDEQHILMPTW

Common Amino Acids R

Mass 3720.38

PI 9.82

Basic Residues 9

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +9

Boman Index 1.24

Hydrophobicity -0.542

Aliphatic Index 25.16

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6335

Absorbance 280nm 170.28

Polar Residues 15

number

Amino Acid Distribution

A: 2 R: 8 N: 0 D: 0 C: 7 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 4 T: 0 W: 0 Y: 4 V: 2

Length

Formula

C152H244N56O40S7

Mass

3720.38

9.82

Net Charge

Boman Index

1.24

Hydrophobicity

-0.542

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.7-1.4 µM

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.7-1.4 uM), S. aureus (MIC 0.7-1.4 uM),L. monocytogenes (MIC 0.7-1.4 uM), E. faecalis (MIC 2.8–5.6 u

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.7-1.4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.7-1.4 uM), S. aureus (MIC 0.7-1.4 uM),L. monocytogenes (MIC 0.7-1.4 uM), E. faecalis (MIC 2.8–5.6 uM), Gram- E. coli D31 (MIC 0

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.7-1.4 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.7-1.4 uM), S. aureus (MIC 0.7-1.4 uM),L. monocytogenes (MIC 0.7-1.4 uM), E. faecalis (MIC 2.8–5.6 uM), Gram- E. coli D31 (MIC 0.35-0.7 uM), S-newport (MIC > 11.2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.35-0.7 µM

Target

Target Organism Escherichia coli D31

Source & Reference

Database Source NA

Other

Evidence Text

s (MIC 0.7-1.4 uM),L. monocytogenes (MIC 0.7-1.4 uM), E. faecalis (MIC 2.8–5.6 uM), Gram- E. coli D31 (MIC 0.35-0.7 uM), S-newport (MIC > 11.2 uM), S. typhimurium (MIC 19-38 uM), B-suis (MIC >11.2 uM), P-aerug

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 19-38 µM

Target

Target Organism S. typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

aecalis (MIC 2.8–5.6 uM), Gram- E. coli D31 (MIC 0.35-0.7 uM), S-newport (MIC > 11.2 uM), S. typhimurium (MIC 19-38 uM), B-suis (MIC >11.2 uM), P-aeruginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. ha

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.8 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source NA

Other

Evidence Text

2 uM), S. typhimurium (MIC 19-38 uM), B-suis (MIC >11.2 uM), P-aeruginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. harvey (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. harvey

Source & Reference

Database Source NA

Other

Evidence Text

8 uM), B-suis (MIC >11.2 uM), P-aeruginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. harvey (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 1.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source NA

Other

Evidence Text

, P-aeruginosa (MIC >11.2 uM), E. aerogenes (MIC 1.4-2.8 uM), V. harvey (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 1.4-2.8 uM), fungi F-oxysporum (MIC >

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source NA

Other

Evidence Text

erogenes (MIC 1.4-2.8 uM), V. harvey (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 1.4-2.8 uM), fungi F-oxysporum (MIC >5.6 uM), and Protozoan P-marinus

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source NA

Other

Evidence Text

rvey (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 1.4-2.8 uM), fungi F-oxysporum (MIC >5.6 uM), and Protozoan P-marinus (MIC >20 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.7-1.4 µM

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.7-1.4 uM), S. aureus (MIC 0.7-1.4 uM),L. monocytogenes (MIC 0.7-1.4 uM), E. faecalis (MIC 2.8–5.6 u

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.7-1.4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.7-1.4 uM), S. aureus (MIC 0.7-1.4 uM),L. monocytogenes (MIC 0.7-1.4 uM), E. faecalis (MIC 2.8–5.6 uM), Gram- E. coli D31 (MIC 0

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.7-1.4 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.35-0.7 µM

Target

Target Organism Escherichia coli D31

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 19-38 µM

Target

Target Organism S. typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.8 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. harvey

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source NA

Other

Evidence Text

rvey (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 1.4-2.8 uM), fungi F-oxysporum (MIC >5.6 uM), and Protozoan P-marinus (MIC >20 uM).

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.7-1.4 µM

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.7-1.4 uM), S. aureus (MIC 0.7-1.4 uM),L. monocytogenes (MIC 0.7-1.4 uM), E. faecalis (MIC 2.8–5.6 u

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.7-1.4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ M. luteus (MIC 0.7-1.4 uM), S. aureus (MIC 0.7-1.4 uM),L. monocytogenes (MIC 0.7-1.4 uM), E. faecalis (MIC 2.8–5.6 uM), Gram- E. coli D31 (MIC 0

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.7-1.4 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.35-0.7 µM

Target

Target Organism Escherichia coli D31

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 19-38 µM

Target

Target Organism S. typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.8 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. harvey

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. vulnificus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.8 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source NA

Other

Evidence Text

rvey (MIC 1.4-2.8 uM), V. alginolyticus (MIC 1.4-2.8 uM), V. vulnificus (MIC 1.4-2.8 uM), V. splendidus (MIC 1.4-2.8 uM), fungi F-oxysporum (MIC >5.6 uM), and Protozoan P-marinus (MIC >20 uM).