Back to search

Peptide record

TPDB11310

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11310
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
C169H292N54O45
ACHMWY
K
3800.51
11.50
11
4
9
+7
14.97
-1.165
81.61
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
5
R
1
N
1
D
0
C
3
E
1
Q
1
G
0
H
3
I
2
L
6
K
0
M
2
F
1
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 1 C: 0 E: 3 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 6 M: 0 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
31
C169H292N54O45
3800.51
11.50
+7
14.97
-1.165
Evidence Records 8 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. albicans. Structure is predicted to be helical based on NMR studies of intact LL-37 and its fragments in micelles.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against C. albicans. Structure is predicted to be helical based on NMR studies of intact LL-37 and its fragments in micelles.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against C. albicans. Structure is predicted to be helical based on NMR studies of intact LL-37 and its fragments in micelles.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

Active against C. albicans. Structure is predicted to be helical based on NMR studies of intact LL-37 and its fragments in micelles.
Evidence 5 Activity

Activity

% Hemolysis
Hemolysis
6 %
[Ref.14978112]6% hemolytic activity at 44 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Immunol 2004 172: 3070-3077.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

6% Hemolysis
Toxicity
44 µM
Hemolytic Cytotoxic
6% Hemolysis | 44 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. | J Immunol | 2004
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.14978112]6% hemolytic activity at 44 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Immunol 2004 172: 3070-3077.
Evidence 8 Hemolysis

Activity

6 %
% Hemolysis
[Ref.14978112]6% hemolytic activity at 44 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
J Immunol 2004 172: 3070-3077.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.